摘要
目的探讨联合检测结核抗体(TBAb)和腺苷脱氨酶(ADA)在结核病诊断的临床应用价值。方法对200例结核病患者进行TBAb和ADA测定,分析它们对结核病诊断的敏感性和特异性。结果结核病组血清及胸水TBAb阳性率分别是71.5%和75.8%,特异性分别是90.5%和93.3%,显著高于对照组(P<0.01),而血清ADA阳性率低,与对照组比较则无差异;结核性胸腔积液患者的胸水ADA阳性率为88.7%,特异性为93.3%,显著高于对照组(P<0.01)。结论测定患者血清中的TBAb和胸水中的TBAb和ADA,对结核病的诊断均有重要的临床价值,两者联合检测,并测定胸水/血清比值对结核性胸膜炎的诊断意义更大。
Objective To explore the joint detection of tuberculosis antibody（TBAb） and adenosine deaminase（ADA） in the diagnosis of tuberculosis in clinical application. Methods 200 cases of tuberculosis patients using TBAb and ADA determination were ied ,and the sensitivity and specificity were analyzed. Results TB in the group, serum and pleural effusion TBAb positive rate was 71.5% and 75.8% ,Specificity was 90.5% and 93.3% ,significantly higher（P 〈0. 01 ） compared with the control group,and serum ADA-positive rate was low compared with the control group. There was no difference; In patients with tuberculosis pleural effusion, pleural effusion ADA- positive rate was 88.7% and specificity was 93.3% ,significantly higher（P 〈0. 01 ） compared with the control group. Conclusion Measurement of serum TBAb, as well as pleural effusion TBAb and ADA, for the diagnosis of tuberculosis have important clinical value, if the two joint detection and determination of pleural effusion/serum ratio for the diagnosis of tuberculosis have more significance.
出处
《临床肺科杂志》
2009年第5期618-619,共2页
Journal of Clinical Pulmonary Medicine
关键词
结核抗体
腺苷脱氨酶
结核病
早期诊断
tuberculosis antibody
adenosine deaminase
tuberculosis
early diagnosis
