摘要
Obiective To investigate the relationship of P- selectin expression and renal diseases. Methods P- selectin expression in renal tissues of patients with glomerulonephritis (n=133) and renalcell carcinoma (n=20) uas detected by immunohistochemistry and in situ hybridization. Results P- selectinexpression was negative in normal kidney.In glomerulonephritis, the up regulated P- selectin expression ontubular opithelium uas significantly higher than that in glomeruli and interstitium, and glomerular P- selectinexpression was significantly up- regulated in group Ⅱ (prominent glomerular cell proliferation) than that in groupⅠ (mild histological lesions in glomeruli) or in group Ⅲ (severe glomerular sclerosis). There was significantcorrelation between the degree of tubulointerstitial lesion and the expression of P- selectin on tubular epithelium orwithin interstitium. P- selectin was positively expressed in Ⅱ cases with renal cell carcinoma (55.0%). The positiveexpression of P- selectin was higher in patients with advanced renal cell carcinoma (Stage Ⅲ and Ⅳ) than earlycases (stage Ⅰ and Ⅱ) (87.5% vs 33.3%, P<0.05). Conclusion The results suggested that P- selectin might playan important role in the early stages of human proliferative glomerulonephritis. The upregulation of P- selectin intubulointerstitium was associated with tubulointerstitial lesions. Furthermore, P - selectin might contribute to thelumor metastasis and the prognosis of renal cell carcinoma.
Obiective To investigate the relationship of P- selectin expression and renal diseases. Methods P- selectin expression in renal tissues of patients with glomerulonephritis (n=133) and renalcell carcinoma (n=20) uas detected by immunohistochemistry and in situ hybridization. Results P- selectinexpression was negative in normal kidney.In glomerulonephritis, the up regulated P- selectin expression ontubular opithelium uas significantly higher than that in glomeruli and interstitium, and glomerular P- selectinexpression was significantly up- regulated in group Ⅱ (prominent glomerular cell proliferation) than that in groupⅠ (mild histological lesions in glomeruli) or in group Ⅲ (severe glomerular sclerosis). There was significantcorrelation between the degree of tubulointerstitial lesion and the expression of P- selectin on tubular epithelium orwithin interstitium. P- selectin was positively expressed in Ⅱ cases with renal cell carcinoma (55.0%). The positiveexpression of P- selectin was higher in patients with advanced renal cell carcinoma (Stage Ⅲ and Ⅳ) than earlycases (stage Ⅰ and Ⅱ) (87.5% vs 33.3%, P<0.05). Conclusion The results suggested that P- selectin might playan important role in the early stages of human proliferative glomerulonephritis. The upregulation of P- selectin intubulointerstitium was associated with tubulointerstitial lesions. Furthermore, P - selectin might contribute to thelumor metastasis and the prognosis of renal cell carcinoma.
