摘要
目的观察斑蝥酸钠维生素B_6注射液(商品名:艾易舒注射液)联合化疗治疗中晚期恶性肿瘤的近期疗效及其对生存质量的影响。方法127例中晚期恶性肿瘤患者随机分为两组,治疗组71例,对照组56例,治疗组和对照组相同的病理、病种选用相同的化疗方案,治疗组在围化疗期加用斑蝥酸钠维生素B_6注射液40 ml静脉滴注,1次/d,14 d为1个疗程,共3～4个疗程;对照组单纯化疗。结果治疗组71例,完全缓解(CR)3例,部分缓解(PR)23例,有效(CR+PR)率36.62%(26/71),对照组56例,CR 1例,PR 10例,有效率19.64%(11/56),两组疗效比较差异具有统计学意义(P<0.05);治疗组疼痛减轻60.56%(43/71),对照组33.93%(19/56),差异具有统计学意义(P<0.01);治疗组体重增加40.85%(29/71),对照组21.43%(12/56),差异具有统计学意义(P<0.05);治疗组Karnof- sky评分提高10分以上66.20%(47/71),对照组41.07%(23/56),差异具有统计学意义(P<0.01);治疗组化疗前后外周血白细胞计数差异无统计学意义(P>0.0 5),对照组化疗后外周血白细胞计数下降明显,差异具有统计学意义(P<0.05)。结论斑蝥酸钠维生素B_6注射液联合化疗能提高化疗疗效,减轻化疗所致骨髓抑制,在改善患者生存质量、减轻疼痛方面也有较好疗效。
Objective To study the effect of the Aiyishu injection combined with chemotherapy for middle and advanced cancer patients in the near future curative effect and survival quality.Methods 127 middle and advanced cancer patients were randomly divided into two groups,71 cases in therapeutic group and 56 cases in control group.The therapeutic group and control group both choose the same sickness plants and combined chemotherapy plan of pathology,therapeutic group added the Aiyishu injection 40 ml to drip. The treatment course lasted 14 days,with 3～4 courses,Simple chemotherapy was used in the control group. Results In the therapeutic group,there were 3 cases of complete response(CR),23 cases,of partial response (PR),the rate of response is 36.62 %(26/71).In the control group,there was 1 case of complete response(CR), 10 cases of partial response(PR),the rate of response is 19.64 %(11/56).There was significant difference be- tween the two groups(P<0.05).The pain relief of therapeutic group was 60.56 %(43/71),and in 33.93 %(19/ 56)control group,there was significant difference between the two groups(P<0.01),weight gain in the thera- peutic group 40.85 %(29/71)and control group 21.43 %(12/56),there was significant difference between the two groups(P<0.05),KPS improved over 10 in the therapeutic group 66.20 %(47/71),and control group 41.07%(23/56),there was significant difference between the two groups(P<0.01).The leukocyte count of pe- ripheral blood in the therapeutic group before and after chemotherapy was not different(P>0.05),whereas it declined significantly in the control group after chemotherapy(P<0.05).Conclusion Aiyishu injection with combined chemotherapy can promote the efficiency of chemotherapy,reduce the arrest of bone marrow,and improve the quality of life,and a good efficiency in pain relieve.
出处
《肿瘤研究与临床》
CAS
2007年第4期256-257,260,共3页
Cancer Research and Clinic
关键词
肿瘤
抗肿瘤联合化疗方案
Neoplasms
Antineoplastic combined chemotherapy protocols
