期刊文献+

分子靶点药物治疗食管癌的临床研究进展 被引量:8

Progress in Molecular Targeted Drug in the Treatment for Esophageal Cancer
原文传递
导出
摘要 药物治疗是食管癌治疗的重要方法之一,但传统意义上的化疗药物因缺乏靶标的选择性,不仅治疗效果欠佳,而且常常产生较为严重的毒副反应,极大地限制了临床的应用。随着对肿瘤发生、发展和转移过程中分子生物学机制研究的不断深入,分子靶点药物的出现为食管癌的治疗带来了新的希望,由于其拥有不易耐药、不受肿瘤周围细胞限制、靶点明确、特异性强、对转移瘤也有较好的效果等特点,正成为研究热点。该文主要综述分子靶点药物在食管癌临床治疗上的新进展。
出处 《中国肿瘤》 CAS 2009年第4期299-303,共5页 China Cancer
作者简介 通讯作者:李苏宜.E-mail:isugi@csco.org.cn
  • 相关文献

参考文献28

  • 1Gibson MK,Abraham SC, Wu TT, et al. Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradio- therapy[J]. Clin Cancer Res, 2003, 9(17):6461-6468.
  • 2Safran H, Suntharalingam M, Dipetrillo T, et al. Cetuximab with concurrent chemoradiation for esophagogastric cancer: assessment of toxicity [J]. Int J Radiat Oncol Biol Phys, 2008, 70(2):391-395.
  • 3Ku GY, Shah MA, Tang LH, et al. Cetuximab (C225) plus irinotecan/cisplatin (CPT/Cis) for CPT/Cis-refractory esophageal cancer[J]. J Clin Oncol, 2008, 26(Suppl):abstr 15580.
  • 4Safran H, DiPetrillo T, Akennan P, et al. Phase Ⅰ/Ⅱ study of trastuzumab, paclitaxel, cisplatin and radiation for locally advanced, HER2 overexpressing, esophageal adenocarcinoma[J]. Int J Radiat Oncol Biol Phys, 2007, 67(2): 405-409.
  • 5Sato S, Kajiyama Y, Sugano M, et al. Monoclonal antibody to HER-2/neu receptor enhances radiosensitivity of esophageal cancer cell lines expressing HER-2/neu oncoprotein[J]. Int J Radiat Oncol Biol Phys, 2005, 61(1):203- 211.
  • 6Janmaat ML, Gallegos-Ruiz MI, Rodriguez JA, et al. Predictive factors for outcome in a phase Ⅱ study of gefitinib in second-line treatment of advanced esophageal cancer patients[J]. J Clin Oncol, 2006, 24(34):5465.
  • 7Ferry DR, Anderson M, Beddard K, et al. A phase Ⅱ study of gefitinib monotherapy in advanced esophageal adenocarcinoma: evidence of gene expression, cellular, and clinical response[J]. Clin Cancer Res, 2007, 13(19): 5869-5875.
  • 8Dobelbower MC, Russo SM, Raisch KP, et al. Epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib, and concurrent 5-fluorouracil, cisplatin and radiotherapy for patients with esophageal cancer: a phase Ⅰ study[J]. Anticancer Drugs, 2006, 17(1):95-102.
  • 9Tew WP, Shah M, Schwartz G, et al. Phase Ⅱ trial of erlotinib for second-line treatment in advanced esophageal cancer [A]. Proc Am Soc Clin Oncol GI Cancers Symposium[C]. New Orleans: ASCO, 2005. abstr 5.
  • 10Enzinger PC, Ryan DP, Regan EM, et al. Phase Ⅱ trial of docetaxel, cisplatin, irinotecan, and bevacizumab in metastatic esophagogastric cancer[J]. J Clin Oncol, 2008, 26(Suppl): abstr 4552.

同被引文献49

引证文献8

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部