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左乙拉西坦对氯化锂-匹鲁卡品致癫癎大鼠模型皮层脑电图的影响 被引量：3

Effect of levetiracetam on electrocorticogram of epileptic rats induced by lithium-pilocarpine
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摘要 目的探讨左乙拉西坦对匹鲁卡品癫癎动物模型皮层脑电图的作用。方法16只动物随机分为左乙拉西坦组和生理盐水对照组。建立氯化锂-匹鲁卡品癫癎动物模型，侧脑室注射左乙拉西坦，观察对皮层脑电图癫癎样放电频率以及脑波频段分布的影响，等容积生理盐水作为对照。结果与生理盐水对照组比较，左乙拉西坦组大鼠皮层脑电图的痈性放电频率明显下降（P〈0．01）；脑电频段分配中β波频段所占比率减少（P〈0．05）。结论左乙拉西坦可以抑制氯化锂-匹鲁卡品癫癎模型急性期皮层脑电图的癎样放电。 Objective To explore the effect of Levetiracetam on Electrocorticogram of epileptic rats induced by lithium-Pilocarpine. Methods Sixteen SD rats were randomly divided into two groups （8 rats in each group）, normal saline group and Levetiracetam group. After epileptic model was induced by lithium-Pilocarpine , lateral ventricle was administered with Levetiracetam and saline by the same volume. The change of frequency of epileptic discharge and different brainwave proportion distribution was observed. Results Compared with normal saline group, the epileptic discharge were significantly decreased （ P 〈 0. 01 ） and the proportion of δ wave was enhanced, meanwhile β wave was decreased in Levetiracetam group （ P 〈 0.05 ）. Conclusion Levetiracetam has the role of anti-epilepsy in acute model of epileptic rats induced by lithium-Pilocarpine.
作者 吴靖 潘松青
机构地区 武汉大学人民医院神经内科
出处 《中国医师杂志》 CAS 2009年第3期312-314,共3页 Journal of Chinese Physician
关键词 吡拉西坦/类似物和衍生物/药理学 癫癎/药物疗法/病理生理学 氯化锂/副作用 毛果芸香础/副作用 脑电描记术 Piracetam/AA/PD Epilepsy/DT/PP Lithium chloride/AE Pilocarpine/AE Electroencephalography
分类号 R742.1 [医药卫生—神经病学与精神病学] R971.6 [医药卫生—药品]
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参考文献7

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共引文献6

同被引文献26

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引证文献3

二级引证文献12

中国医师杂志
2009年 第3期

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