摘要
目的:分析肝细胞癌(HCC)患者肿瘤切除术前、术后血浆骨桥蛋白(OPN)表达水平和术后转移复发及其与生存预后之间的关系,评价联合检测术前、术后血浆OPN表达在预测肝癌术后复发及预后中的作用。方法:测定56例HCC患者术前、术后血浆OPN表达水平,并收集其临床病理资料及随访资料,统计分析血浆OPN表达水平和患者术后肿瘤复发及生存预后的关系,并根据术前、术后OPN表达水平进行分组,分析其与HCC患者术后转移、复发及生存的关系。结果:术前OPN高、低表达组患者术后1年复发率分别为52.6%和24.3%(P<0.05);累积无瘤生存率为43.9%和70.5%(P<0.05);术后OPN高、低表达组患者术后1年复发率为58.3%和15.6%(P<0.01);累积无瘤生存率为36.7%和81.7%(P<0.01)。联合术前、术后OPN表达对患者进行分组,高、中、低表达组患者术后1年复发率分别为70.0%、41.7%和9.1%(P<0.01);累积无瘤生存率为26.7%、54.7%和85.9%(P<0.01)。术前、术后OPN单独预测1年复发的特异度分别为75.7%、72.9%,联合两指标筛选高复发风险患者的特异度为91.9%,高于相应的单个指标(P<0.05)。结论:术前、术后血浆OPN表达水平与HCC患者预后相关,联合分析术前、术后OPN表达,可以筛选出更高复发风险患者。
Objective： To investigate the association of preoperative and postoperative plasma osteopontin （OPN） levels with tumor recurrence and prognosis in patients with hepatocellular carcinoma （HCC） after surgical resection. Methods： A total of 56 patients received liver resection for HCC were enrolled in this study. The association of the OPN levels with the clinicopathological characteristics, tumor recurrence, and disease-free survival （DFS） of HCC patients was analyzed. The associations of each marker or their combination with HCC recurrence and prognosis of HCC patients were studied. Results： The 1-year recurrent rates were 52.6% and 24.3% （P 〈 0.05）, DFS rates were 43.9% and 70.5% （P 〈 0.05）, respectively in higher and lower preoperative OPN level groups. The 1-year recurrent rates of higher and lower postoperative OPN level groups were 58.3% and 15.6% （P 〈 0.01）; DFS rates were 36.7% and 81.7% （P 〈 0.01）, respectively. Combined assessing preoperative and postoperative OPN levels, the 1 -year recurrent rates of the higher, middle and lower level groups were 70.0%, 41.7% and 9.1% （P 〈 0.01）; DFS rates were 26.7%, 54.7% and 85.9% （ P 〈 0.01 ）, respectively. The 1-year predictive specificity of preoperative and postoperative OPN was 75.7% and 72.9% respectively. Combination of the two markers could achieve a specificity of 91.9% for 1 year, higher than that of single marker （P 〈 0.05）. Conclusion： The expression levels of plasma OPN were associated with postoperative recurrence and prognosis in patients with HCC. The combined evaluation of preoperative and postoperative plasma OPN levels may be helpful to predict the prognosis of HCC in patients after operation.
出处
《天津医药》
CAS
北大核心
2009年第3期177-179,共3页
Tianjin Medical Journal
关键词
癌
肝细胞
唾液糖蛋白类
复发
手术期间
预后
酶联免疫吸附测定
carcinoma,hepatocellular sialoglycoproteins recurrence intraoperative period prognosis enzymelinked immunosorbent assay
