摘要
目的系统评价夹脊穴治疗带状疱疹临床随机对照试验疗效,为夹脊穴治疗该病的推广应用提供理论依据。方法计算机检索CNKI、VIP、万方数据库、CBM,手工检索天津中医药大学图书馆过刊资料库及相关会议论文集,收集夹脊穴治疗带状疱疹临床随机对照试验,由两名评价者独立提取资料并进行方法学质量评估。统计学分析采用RevMan4.2.8软件。结果共纳入14个随机对照试验(共1394例)。Meta分析结果显示,①总有效率:夹脊穴与消炎痛、维生素[RR=1.28,95%CI(1.13,1.43)]及卡马西平[RR=1.33,95%CI(1.15,1.55)]和常规针刺[RR=1.22,95%CI(1.14,1.32)]有差别,与阿昔洛韦[RR=1.07,95%CI(0.98,1.16)]无差别。②临床治愈率:夹脊穴与消炎痛、维生素[RR=2.27,95%CI(1.68,3.06)]、与阿昔洛韦[RR=1.29,95%CI(1.07,1.56)]、卡马西平[RR=3.31,95%CI(2.18,5.03)]和常规针刺[RR=1.59,95%CI(1.33,1.90)]有差别。③临床症状评分情况:夹脊穴与消炎痛、维生素,疼痛、灼热感、瘙痒、睡眠分别为[WMD=1.84,95%CI(1.06,2.61)]、[WMD=1.87,95%CI(1.23,2.51)]、[WMD=0.90,95%CI(0.84,0.97)]和[WMD=1.64,95%CI(0.56,2.71)]有差别。④VAS评分情况:夹脊穴与卡马西平[WMD=3.34,95%CI(1.63,5.17)]、阿昔洛韦[WMD=2.27,95%CI(2.16,2.38)]、常规针刺[WMD=3.37,95%CI(1.63,5.74)]有差别。结论夹脊穴治疗带状疱疹的疗效与西药及常规针刺比较有差别。但尚需要更多高质量的随机双盲对照试验来进一步证实夹脊穴治疗带状疱疹的疗效。
Objective To evaluate the curative effect of Jiaji points on herpes zoster ; and to provide the theory evidence for application. Methods Randomized controlled trials （RCTs） involving Jiaji points the treatment of herpes zoster were identified from CNKI, VIP, Wanfang Database and CBM. We also hand searched relevant journals and conference proceedings. The data were extracted and evaluated by two reviewers independently with a specially designed extraction form. The Cochrane Collaboration＇s RevMan 4.2.8 software was used for data analyses. Results A total of 14 trials involving 1 394 patients were included. Meta-analyses showed that the total effective rate were similar between Jiaji points group and aciclovir group （RR 1.07, 95%CI 0.98 to 1.16）, but discrepant when compared with indomethacin and vitamin group（RR=1.28, 95%CI 1.13 to 1.43）, carbamazepine group （RR=1.33, 95%CI 1.15 to 1.55）and conventional acupuncture group （RR=1.22, 95%CI 1.1d to 1.32）.As for the clinical cure rate, significant difference was noted between Jiaji points group and indomethacin and vitamin group（RR=2.27, 95%CI 1.68 to 3.06）, or aciclovir group （RR=1.29, 95%CI 1.07 to 1.56）, or carbamazepine group （RR 3.31, 95%CI 2.18 to 5.03）, or conventional acupuncture group （RR=1.59, 95%CI 1.33 to 1.90）. As for the clinical symptoms scores, significant difference was noted between Jiaji points group and indomethacin and vitamin group, including ache score （WMD=1.84, 95%CI 1.06 to 2.61）, burning heat sensation （WMD=1.87, 95%CI 1.23 to 2.51）, itch （WMD=0.90, 95%CI 0.84 to 0.97）, and slumber （WMD=1.64, 95%CI 10.56 to 2.71）. In terms of the VAS scores, significant differences were noted between Jiaji points group and carbamazepine group（WMD=3.34, 95%CI 1.63 to 5.17）, or aciclovir group（WMD=2.27, 95%CI 2.16 to 2.38）, or conventional acupuncture group （WMD=3.37, 95%CI 1.63 to 5.74）. Conclusion The profit treated by Jiaji points on herpes zoster is superior to that in the control group. Further large-scale trials are required to define the role of acupuncture in the treatment of herpes zoster.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2009年第2期112-117,共6页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
关键词
夹脊穴
带状疱疹
随机对照试验
系统评价
Jiaji points
herpes zoster
clinical randomized controlled trial
system veview
