摘要
目的观察小檗碱治疗冠心病合并糖耐量异常的疗效及毒副作用。方法冠心病合并糖耐量异常患者52例,常规治疗基础上加用小檗碱,治疗12周,于治疗前后分别检测空腹血糖、餐后2h血糖、糖化血红蛋白水平、治疗前后甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇,以评价小檗碱的治疗效果。结果与治疗前相比,小檗碱能有效降低空腹血糖、餐后2h血糖水平、糖化血红蛋白水平(P<0.01),能降低甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平(P<0.05),未发现明显毒副作用。结论小檗碱可显著改善冠心病合并糖耐量异常患者血糖、血脂水平,无明显毒副作用,物美价廉,值得临床关注。
Objective To study the efficacy and safety of the berberine therapy in patients with coronary heart disease complicated with impaired glucose tolerance（IGT）. Methods The administration was berberine 500mg, 3 times daily, for 52 cases of coronary heart disease complicated IGT. The patients were followed for 12 weeks. Determination of FPG,2hPG,TC,TG and HDL before and after the therapy. Results Both FPG and 2hPG decreased obviously after 12 weeks of treating（P 〈 0.01 ）;TG ,TC, LDL were obviously decreased after 12 weeks of treating（P 〈 0.05 ）. Conclusion The berberine therapy is effective, safe and economic to coronary heart disease with impaired glucose tolerance.
出处
《中国现代医生》
2009年第7期74-75,共2页
China Modern Doctor
关键词
小檗碱
冠心病
糖耐量异常
Berberine
Coronary heart disease
Impaired glucose tolerance
