摘要
目的探讨吗啡在急性左心衰院前急救过程中的临床效果及安全性。方法96例急性左心衰院前患者随机分成吗啡组和对照组,每组48例,吗啡组在常规治疗基础上给予吗啡10 mg,用药前、用药后5 min、10 min、15 min、30 min、60 min分别测定两组患者的呼吸、心率、血压、血氧饱和度以及症状体征等变化。结果对照组显效10例,有效18例,无效17例,死亡3例,院前气管插管3例;吗啡组显效19例,有效19例,无效5例,死亡5例,院前气管插管10例。对照组总有效率58.3%,病死率6.3%;吗啡组总有效率79.2%,病死率10.4%。结论急性左心衰院前急救中应综合考虑院前急救抢救人员不足、抢救设备有限、抢救药物有限的客观条件,高度警惕使用吗啡后的呼吸抑制,院前急救中应慎用吗啡。
Objective To investigate the efficacy and safety of morphine in patients with acute left heart failure（ALHF） during fist aid outside hospital. Methods Ninty-six patients with ALHF were randomly divided into two groups：group A and group B.Group A（n=48）was received usual therapy such as monitoring RR,HR,BP,SPO2,breathing in oxygen,increasing heart,diuresis,relieving spasm,pressing wheeze.Group B（n=48）was received morphine and usual therapy.The effect was assessed with symptom of patients. Results In group A the effect of 10 patients was significant and that of 18 patients was general and 17 patients were ineffective,3 patients were dead and 3 patients need to insert tube.In group A the general effective rate was 58.3% and death rate was 6.3%.In group B 19 patients had significant effect,19 patients were general,5 patients were ineffective,5 patients were dead and 10 patients need to insert tube.In group B the general effective rate was 79.2% and death rate was 10.4%.Conclusion Morphine is an effective drug in treating patients with ALHF.But morphine has side effect of resisting breath.In the first aid outside hospital morphine needs to be used under the condition of sufficient facilities and technology controlled by doctors and nurses.
出处
《南华大学学报（医学版）》
2008年第5期630-632,共3页
Journal of Nanhua University(Medical Edition)
关键词
吗啡
急性左心衰
院前急救
安全性
morphine
acute left heart failure
first aid outside hospital
safety
作者简介
通讯作者：谭建新，电话：13926686527；E—mail：tjx1972@21cn．com．
