摘要
目的研究脑出血患者静脉血清和颅内血肿液中白细胞介素4(IL-4)、白细胞介素6(IL-6)含量的动态变化,探讨IL-4、IL-6与脑出血的关系和意义。方法检测89例急性脑出血患者静脉血清和颅内血肿液中IL-4、IL-6含量,并与正常对照组进行对比。结果急性期脑出血患者静脉血清和颅内血肿液中IL-4、IL-6含量均明显高于正常对照组,IL-4(63.6±23.7)ng/L、(60.9±23.4)ng/Lvs(17.9±7.1)ng/L(P<0.01),IL-6(91.6±23.7)ng/L、(90.2±29.6)ng/Lvs(34.5±17.2)ng/L(P<0.01);脑出血不同时期(<6h,6～12h,>12～24h,>24～72h,>3～7d)静脉血清IL-4、IL-6含量比较,>24～72小时含量最高,此后呈下降趋势。结论IL-4、IL-6参与了脑出血急性期的炎症反应,是脑出血后脑组织损伤的重要机制之一。
Objective To investigate the relationship between IL-4,IL-6 and intracerebral hemorrhage（ICH） by studying the dynamics of IL-4 and IL-6 levels in venous serum and hematoma fluid of patients. Methods IL-4 and IL-6 in venous serum and hematoma fluid were assayed in 89 patients with intracerebral hemorrhage（ICH group）, then compared with those of normal control group. Results The levels of IL-4 and IL-6 in venous serum and hematoma fluid in ICH group were higher than those of normal control group, IL-4 （63.6± 23.7） ng/L, （60.9± 23.4） ng/L vs （17.9±7.1） ng/L （P 〈 0.01）,IL-6（91.6±23.7） ng/L, （90.2± 29.6） ng/L vs （34.5±17.2） ng/L（ P 〈0.01）. When comparing the levels of IL-4,IL-6 at different ICH stages （〈6 h,6-12 h,〉12-24 h,〉24-72 h,〉3-7 d）, the highest levels were detected during 24-72 h followed by a tendency to decrease after 72 h. Conclusion IL-4,IL-6 have participated in the inflammation reaction in acute ICH,which could be one of significant mechanism in brain tissues injury.
出处
《临床荟萃》
CAS
2009年第6期478-480,共3页
Clinical Focus
基金
河北省科学技术研究与发展指导计划项目(062761297)
作者简介
通讯作者：台立稳，Email：Tailiwen@sina．com.
