摘要
目的研究化疗药物对异位癌肿并癌前病变患者胃组织匀浆中癌胚抗原(CEA)表达的影响。方法30例结直肠癌和15例食管癌患者(肿瘤组)中,其化疗前经胃镜检查均示不典型增生或肠上皮化生。在化疗前及化疗6周期后分别行胃镜检查,在同一部位取胃组织,测定胃组织匀浆中的CEA表达。另取10例肿瘤患者的正常胃黏膜组织作为对照组。结果肿瘤组胃组织匀浆中的CEA表达明显高于对照组,且随癌前病变程度加重CEA表达升高,化疗6周期后其CEA表达降低;治疗前后轻中度癌前病变组织CEA降低有统计学差异,而重度癌前病变组织CEA降低无统计学差异。结论化疗药物可明显降低轻中度癌前病变患者胃组织匀浆中的CEA表达,逆转轻中度癌前病变。
Objective To investigate the effect of chemotherapy drugs on the expression of carcinoembryonic antigen （CEA） in stomach tissue with precancerous lesions in ectopic cancer. Methods There were 30 cases of colorectal cancer patients and 15 cases of esophageal cancer patients（ cancer group）. The pathologyical biopsy showed that there were atypical hyperplasia or intestinal metaplasia by gastroscope before chemotherapy. Gastroscope was done before chemotherapy and after six cycles of chemotherapy. Gastric tissue was taken respectively in the same position. The expression of CEA was measured in the gastric tissue. Normal gastric tissue taken from 10 cases of cancer patients was served as control. Results The expression of CEA in the gastric tissue in the cancer group was higher than that in the control group and its level would be increased with the malignant progression. The expression of CEA was reduced after six cycles of chemotherapy. In the mild to moderate precancerous lesions group pretherapy and post treatment, the reduction was significantly reduced. However, there was no statistical difference in the severe precancerous lesions group pretherapy and post treatment. Conclusions Chemotherapy drugs can significantly reduce the expression of CEA in the gastric tissue in the mild to moderate precancerous lesions group and reverse the mild to moderate precancerous lesions.
出处
《山东医药》
CAS
北大核心
2009年第5期28-30,共3页
Shandong Medical Journal
基金
济南市卫生局科技计划项目(济卫科字2004第36号)
关键词
胃肿瘤
癌前病变
异位肿瘤
癌胚抗原
gastric cancer
precancerous lesions
ectopic cancer
carcinoembryonic antigen
作者简介
通讯作者
