摘要
目的:探讨嗅神经母细胞瘤的诊断和治疗及预后。方法:回顾分析1998年-2002年收治的10例嗅神经母细胞瘤的临床资料。4例标本行透射电镜观察。根据Kadish分期:A期2例,B期4例,C期4例。单纯手术3例,手术加放疗7例。结果:1例失访,其余9例获得随访。5年生存率60%(6/10),3例死于局部复发。电镜检查4例中的3例肿瘤细胞可见神经内分泌颗粒。结论:手术加放疗可以提高嗅神经母细胞瘤的局部控制率。电镜观察有助于该肿瘤的诊断和鉴别诊断。
Objective： To review the diagnosis, treatment and prognosis of olfactory neuroblastoma. Methods： Clinical data were retrospectively reviewed in 10 cases of olfactory neuroblastoma admitted from 1998 to 2002,including data of transmission electron microscopic （TEM） observation in 4 cases. According to Kadish＇s classification,2 cases were in stage A,4 in stage B and 4 in stage C. Three patients were treated with surgery alone, 7 with combined surgery and radiation. Results： Among 10 cases,the overall 5-year survival rate was 60G （6/10） ; 3 patients died from local recurrence, 1 lost follow up. TEM demonstrated granules in the cytoplasm of 3 patients. Conclusions： The combined surgery and radiation can achieve excellent local control. Transmission electron microscope is important for its diagnosis.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2009年第1期103-106,共4页
Journal of Zhejiang University(Medical Sciences)
作者简介
王华林（1965-），男，医学硕士，副主任医师，从事耳鼻咽喉科工作；E-mail：hzwhl@hotmail．com
