摘要
创伤后应激障碍是个体经历严重应激后形成的一种焦虑障碍,对其治疗的关键是消退由创伤应激导致的条件性恐惧记忆,但目前最有效的暴露疗法并不能真正有效地抑制患者恐惧记忆的表达。对条件性恐惧的动物模型研究发现情绪性增强效应、恐惧记忆二级条件化与再巩固、内侧前额叶皮层功能不足等均能够阻碍条件性恐惧记忆的消退。针对这几个方面可以探索治疗创伤后应激障碍的相应方法。
Posttraumatic stress disorder is a kind of anxiety disorder which developed after severe trauma. The key of treatment for this disorder is to extinct the conditioned fear memory acquired in trauma. But the most effective exposure therapy can＇t repress fear memory efficiently. Researches from animal model of fear conditioning showed that： enhancing effects of emotional arousal, secondary-order conditioning and reconsolidation of fear memory, deficient function of medial prefrontal cortex etc all are reasons block the extinction of fear memory. According to these reasons, corresponding treatment ways can be explored and developed.
出处
《心理科学进展》
CSSCI
CSCD
北大核心
2009年第1期126-131,共6页
Advances in Psychological Science
基金
国家自然科学基金(30470578,30770722,30840001)
中国科学院心理研究所科学发展基金资助
关键词
条件性恐惧记忆
消退
情绪性增强效应
二级条件化
再巩固
内侧前额叶皮层
conditioned fear memory
extinction
emotional enhancing effect
secondary-order conditioning
reconsolidation
medial prefrontal cortex
作者简介
通讯作者：郑希耕，E-mail：zhengxg@psych．ac．cn
