摘要
以家兔为实验动物，经同剂量ＬＮＴ－ｒＩＬ－２和ｒＩＬ－２多次免疫，ＥＬＩＳＡ法分析两者免疫血清中抗体（ＩｇＧ）滴度，结果显示：ＬＮＴ－ｒＩＬ－２免疫血清中特异抗体滴度与ｒＩＬ－２对照组无显著性差异（Ｐ＜０．１），但总体水平有一定程度下降；ＬＮＴ呈现弱免疫原性。提示ＬＮＴ－ｒＩＬ－２的免疫原性并未由于修饰作用而增强，而是有下降趋势，可能与ＬＮＴ对ｒＩＬ－２的空间位阻等因素有关。
Family rabbits were used for test, being immunized several times by same doses of LNTrIL2 and rIL2, analysed both of the antibody titres of immune serums by ELISA method. Results demonstrated that the specific antibody titres immunized by LNTrIL2 had no significant different than that of rIL2 group(P<01). But the total titre level had some reduction ;the Lentinan was found to have lower immunogenicity. These indicated that LNTrIL2 immunogenicity had not been increased by the modification of Lentinan, whereas found some reduction, perhaps by reason of the steric hindrance of Lentinan against rIL2.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1998年第2期89-91,共3页
Chinese Journal of Immunology
基金
国家八五科技攻关计划资助
