摘要
用ＨｙｐｅｒｓｉｌＯＤＳ色谱柱，以甲醇－水－磷酸（６０∶４０∶０．１８）为流动相，采用反相高效液相色谱法测定血浆中格列吡嗪浓度。方法回收率高，结果准确，重现性好。
HPLC method for the determination of glipizide in plasma was developed. The chromatographic conditions were: mobile phase, methanolwaterphosphoric acid (60∶40∶0.18);column, Hypersil ODS(4.5 i d×250mm); flow rate, 0.8ml/min; column temperature, 60°C. The UV detector (275nm). Response was linear over a range of 20￣1000ng/ml. The average recovery and precision of the method were satisfactory.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1998年第2期78-81,共4页
Chinese Journal of Pharmaceuticals
关键词
格列吡嗪
血药浓度
缓释片
高效液相色谱
glipizide, plasma concentration, sustained release tablets, HPLC, determination
