摘要
为了了解淋巴细胞粘附分子与斑秃发病的关系,应用FACScan流式细胞仪,对斑秃患者外周血淋巴细胞CD_(54)分子的表达进行了定量研究。结果显示:(1)斑秃患者的淋巴细胞CD_(54)表达量较对照组显著增高(P<0.001)。(2)全秃患者淋巴细胞CD_(54)分子表达量明显高于局限性患者(P<0.05)。(3)患者淋巴细胞CD_(54)分子表达量与病程长短无关。提示淋巴细胞粘附分子可能在斑秃发病中起重要作用。
In order to understand the relationship between lymphocyte-adhesion molecule and pathogenesis of alopecia areata, expression of CD54 on lymphocytes from patients with alopecia areata were detected by using flow cytometry. The results were as follows; (1)Compared with normal subjects,increased expression of CD54 on lymphocytes from patients was observed(P<0. 001). (2)Expression of CD54 in generalized lesion group was increased compared with localized lesion group(P<0. 05). (3)There was no correlation between expression of CD54 and course of the disease. It is suggested that CD54 molecule may play an important role in the pathogenesis of alopecia areata.
出处
《天津医药》
CAS
1998年第3期142-143,共2页
Tianjin Medical Journal
