摘要
脂多糖（1ipopolysaccharide，LPS）又称内毒素，是革兰阴性细菌外膜的主要成分。LPS与急性期蛋白脂多糖结合蛋白（lipopolysaccharide binding protein，LBP）结合，可导致炎症反应失控及免疫防御屏障机能下降，引起全身炎性反应综合征、脓毒性休克、急性肺损伤甚至多器官功能障碍综合征。另有研究表明LBP亦有抗炎作用，LBP发挥不同的作用是由不同的功能位点决定的。因此说LBP在炎症反应中有双韧剑的作用。
Lipopolysaccharide（LPS）,also called endotoxin,is the main component of the bacterial cell wall. After its release from bacteria, LPS can bind to a specific binding protein, known as lipopolysaccharide binding protein（LBP）. The amplification of LPS effects mediated by LBP may be detrimental to the host, which results in systemic inflammatory response syndrome,acute lung injury and multiple organ dysfunction syndrome. Another study shows an inhibitory role of high concentrations of LBP in the LPS-induced inflammatory response. The diverse function of LBP is determined by diverse sites. Therefore, LBP is a twoedge sword in inflammatory reaction.
出处
《国际呼吸杂志》
2009年第1期39-43,共5页
International Journal of Respiration
基金
基金项目：国家自然科学基金资助课题（30170366）
关键词
脂多糖
脂多糖结合蛋白
内毒素血症
Lipopolysaccharide
Lipopolysaccharide binding protein
Endotoxemia
