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ω-3多不饱和脂肪酸对结肠癌的影响 被引量：6

Effects of ω-3 Polyunsaturated Fatty Acids on Colon Cancer
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摘要 ω-3多不饱和脂肪酸(ω-3PUFA)主要来源于鱼油,是细胞结构和功能重要组成成分,对细胞免疫应答调节和抑制发挥重要作用。ω-3PUFA可通过影响细胞膜脂质组成、调控脂类代谢水平及细胞内基因编码等多种途径,阻滞结肠癌细胞生长周期、抑制细胞增殖、促进细胞分化和诱导癌细胞凋亡,显著抑制结肠癌生长和转移,还可改善肿瘤恶病质患者体质,提高其存活率。 Omega-3 polyunstaurated fatty acids （ω-3PUFA） , mainly derived from fish oils, are essential for the integrity and function of the cells and play a key role as immune response modulators and suppressors of immunologic functions, ω-3PUFA can effectively inhibit the growth and metastasis of colon cancer by inhibiting cell proliferation, promoting cell differentiation, and inducing tumor cell apoptosis by profoundly altering the biochemical make-up of cell membrane lipid composition, regulating the level of lipid metabolism, and modulating the expression of intracelluar genes encoding, ω-3PUFA may also improve the patient＇s immunologic functions and increase the survival rate.
作者 刘敬武 尉承泽
机构地区 军事医学科学院附属
出处 《中国临床营养杂志》 2008年第6期371-376,共6页 Chinese Journal of Clinical Nutrition
关键词 Ω-3多不饱和脂肪酸 结肠癌 抑制 ω-3 polyunsaturated fatty acids colon cancer inhibition
分类号 R735.35 [医药卫生—肿瘤]
作者简介 通信作者主任医师教授，电话：010—66947146，电子邮件：yuchengze@sina．com
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参考文献28

  • 1Chapkin RS, McMurray DN, Lupton JR. Colon cancer, fatty acids and anti-inflammatory compounds [ J ]. Curr Opin Gastroenterol, 2007, 23 ( 1 ) :48-54.
  • 2Mayer K, Meyer S, Reinholz-Muhly M, et al. Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans [J]. J Immunol, 2003, 171(9) :4837-4843.
  • 3Chapkin RS, Davidson LA, Ly L, et al. Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancer [J]. Nutr, 2007, 137(3) :S200-S204.
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二级参考文献9

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中国临床营养杂志
2008年 第6期

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