摘要
目的评价床旁检测(POCT)血糖和糖化血红蛋白(HbAlc)的准确性及其应用价值。方法对88例疑似糖尿病者行POCT方法测定HbAlc和实验室方法测定血浆血糖及HbAlc。将POCT方法测定毛细血管血糖及HbAlc的结果与相应静脉血的实验室测定结果作比较,评估POCT与实验室方法检测血糖和HbAlc的相关系数、平均偏差和一致性限度(LOA)等,进行横断面研究。结果两种方法测定值的相关系数为:血糖r=0.98,HbAlc r=0.95。血糖的平均偏差为0.36 mmol/L(95%CI: 0.13～0.62,ILOA:-2.07～2.79 mmol/L;P=0.007),HbAlc的平均偏差为0.02%(95%CI:-0.07%～0.09%;LOA:-0.66%～0.68%;P=0.95)。结论POCT检测HbAlc的结果准确可靠,方便实用,适于社区居民现场检测,以监测DM的疗效;而POCT检测血糖的结果尚需通过实验室血糖检测进行定期校正,不能直接用于DM诊断。
Objective To assess tile accuracy and application values of point-of-care testing （POCT） of capillary blood glucose and glycosylated hacmoglobin（Hbalc） levels. Methods 152 resi dents （aged 21-75 years） were recruited, who had POCT glucose measurements in October 2006. Eighty eight cases with POCT glucose level≥5. 0 mmol/L,or self-reported diabetes mellitus（DM）. Thereafter,88 cases had POCT H bAlc and laboratory glucose and HbAlc measurements, respectively. The POCT and laboratory measurements of glucose and HbAlc were compared,and the correlation co efficient r,mean difference and limits of agreement（LOA） between capillary POCT and venous blood laboratory measurements of glucose and HbAlc were evaluated for cross-sectional study. Results Mean and median POCT capillary glucose levels were 7.99 mmol/L and 6.25 mmol/L, respectively, while mean and median laboratory venous plasma glucose concentrations were 7.63 mmol/L and 5.35 mmol/L. Mean and median of POCT capillary HhAlc and laboratory HhAlc were 6.98% and 5.96%, and those of laboratory HbAlc were 7.06% and 6.0%, respectively. The correlation coefficient r for POCT and laboratory results was 0.98 for glucose and 0.95 for HbAlc. The mean difference in results was 0.36 mmol/L for glucose（ 95% CI：0. 13-0. 62;LOA： - 2.07-2. 79 mmol/L,P= 0. 007）and 0.02% for HbAlc（95% CI：- 2. 07%-0.09%;LOA：-0. 66%-0. 68%;P= 0. 95）,respectively. Conclusion POCT capillary t.oAlc testing offers an accurate,practical and convenient way of monito ring the therapy effects of diabetes in community. While POCT capillary glucose results should be calibrated regularly by a laboratory test of venous plasma,it couldh＇t be directly used to diagnos DM.
出处
《国际检验医学杂志》
CAS
2008年第12期1093-1095,共3页
International Journal of Laboratory Medicine
关键词
血糖
血红蛋白A
糖基化
临床实验室技术
Blood Glucose
Hemoglobin A,Glycosylated
Clinical Laboratory Techniques
