摘要
胰腺癌是常见的消化道恶性肿瘤,传统的化疗和放疗效果均不甚理想。表皮生长因子受体(EGFR)信号转导通路在胰腺癌细胞的增殖、转移、血管形成等方面有重要作用,因此,针对EGFR信号通路的新型药物已陆续开发和应用。此文综述了EGFR的结构、功能以及EGFR抑制剂在胰腺癌治疗中的作用。
Pancreatic carcinoma is an unusually gastroenterology tumor and to date treatment with standard chemotherapy has yielded disappointing results. The epidermal growth factor receptor（EGFR）is over-expressed and plays an important role in proliferation,migration,neo vascularization. Novel antineoplastics are developed by preferentially targeting inhibition of EGFR. The structures and functions of EGFR as well as current status of EGFR inhibitors are reviewed.
出处
《国际消化病杂志》
CAS
2008年第6期446-448,454,共4页
International Journal of Digestive Diseases
作者简介
通讯作者：吴叔明，E-mail：wushuming@vip．sina．com
