摘要
目的研究妊娠晚期隐性梅毒TRUST血清学固定患者细胞免疫功能的变化。方法应用流式细胞仪检测妊娠晚期隐性梅毒血清学固定24例患者及16例健康对照的女性外周血淋巴细胞亚群,并用ELISA方法检测两组外周血IL-10及IL-12浓度水平。结果妊娠晚期隐性梅毒RPR血清固定患者外周血细胞亚群与健康对照组比较,CD3+、CD8+淋巴细胞及B细胞差异无显著性(P>0.05),CD4+淋巴细胞、NK细胞明显降低(P<0.O1),CD4+/CD8+显著降低(P<0.O1)。IL-10及IL-12浓度水平无显著性差异(P>0.05),IL-10/IL-12浓度比值显著性降低(P<0.O1)。结论妊娠晚期隐性梅毒RPR血清固定患者存在细胞因子分泌的不平衡,导致细胞免疫功能不平衡和免疫抑制,在妊娠晚期隐性梅毒患者RPR血清固定病程中起着一定的作用。
Objective To observe the changes of the profile of lymphocyte subsets of perpheral blood in lying-in women with latent syphilis （PLLS）. Methods Lymphocyte subsets and NK cell were determined by flow cytometry （FCM） in peripheral blood of 24 PLLS with sew-resistance and 16 healthy women. Results Compared ti that of the healthy contol group the levels of CD3^＋,CD8^＋ and B lymphocyte subsets in the syphilis patients were significantly defferent（P〉0.05）. But the levels of CD4^＋,NK lymphocyte subsets in he patients group were significantly lower than that of the healthy controls group （P〈0.01）. The concentrations of IL-10 and IL-12 in perpheral blood of syphilis patients were significantly higher than that of the healthy controls（P〈0.01）. Conclusions The results suggest that patients of PLLS had unbalanced secretion of cytokine. This phenomenon could result in imbalance and suppression of cellular immunity in patients of PLLS, which might play an important role in development of sero-resistance in the patient of PLLS.
出处
《中国热带医学》
CAS
2009年第1期16-18,共3页
China Tropical Medicine
基金
深圳市科技局项目(项目编号:JH200507131003A)
作者简介
李真：副主任医师，主要从事皮肤病和性病临床及性病预防与控制工作。
