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肿瘤患者二氢嘧啶脱氢酶基因单核苷酸多态性分析 被引量：5

An Analysis of Single Nucleotide Polymorphism of Dihydropyrimidine Dehydrogenase Gene in Patients with Cancer
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摘要 [目的]检测中国大陆肿瘤患者二氢嘧啶脱氢酶(DPD)基因Exon2、Exon13、Exon14和Exon18的单核苷酸多态性(SNP)类型及其发生频率,观察此SNP是否存在种族差异。[方法]2004年10月～2005年8月随机收集142例患者血标本,其中鼻咽癌患者60例,结直肠癌患者82例。采用PCR技术扩增DPYD基因的Exon2、Exon13、Exon14和Exon18外显子,从正反两个方向对扩增片段进行DNA测序和分析。[结果]在DPYD基因Exon2、Exon13、Exon14、Exon18中发现4种SNP,即T85C(7.04%)、A1627G(20.77%)、T1896C(11.62%)和G2194A(0.70%)。C61T、G62A、A74G、G1601A、T1679G、C1714G和GIVS14+1ASNP在本研究中未发现。[结论]中国大陆肿瘤患者DPD基因Exon2、Exon13、Exon14、Exon18中存在4种SNP,分别为T85C、A1627G、T1896C和G2194A。
作者 何义富 王风华 张星 李苏 李志铭 李宇红 张东生 季楚舒 胡冰 姜文奇
机构地区 安徽医科大学附属省立医院 中山大学肿瘤防治中心
出处 《中国肿瘤》 CAS 2008年第12期1044-1047,共4页 China Cancer
基金 广州市科技计划项目期(2003J1-C0051)
关键词 氟尿嘧啶 二氢嘧啶脱氢酶 单核苷酸多态性
分类号 R730.264 [医药卫生—肿瘤]
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参考文献14

  • 1Milano G, Etience MC. Dihydropyrimidine dehydrogenase (DPD) and clinical pharmacology of 5-fluorouracil[J]. Anticancer Res, 1994, 14(6A) : 2295-2297.
  • 2Harry BE, Song R, Soong S, et al. Ralationship between dihydropyrlmidine dehydrogenase activity and plasma 5- fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion [J]. Cancer Res, 1990, 50(1): 197-201.
  • 3Johnson MR, Wang K, Tilhnanns S, et al. Strctural organization of the human dihdropyrimidine deghydrogenase gene[J]. Cancer Res, 1997, 57(9): 1660-1663.
  • 4Bertilsson L. Geogrophical/interracial difference in polymorphic drug oxidation[J]. Clin Pharmacokinet, 1995, 29 (3): 192-209.
  • 5Wei X, McLeod HL, McMurrough J, et al. Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity[J]. J Clin Invest, 1996, 98(3): 610-615.
  • 6van Kuilenburg AB.Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil[J]. Eur J Cancer, 2004, 40(7) : 939-950.
  • 7Hsiao HH, Yang MY, Chang JG, et al. Dihydropyrimidine dehydrogenase pharmacogenetics in the Taiwan Residents population[J].Cancer Chemother Pharmacol,2004,53(5):445-451.
  • 8Mcleod HL, Collie-Duguid ESR, Vreken P, et al. Nomenclature for human DPYD alleles [J]. Pharmaeogenetics, 1998, 8(6) :455-459.
  • 9Ridge SA, Sludden J, Brown O, et al. Dihydropyrimidine dehydrogenase pharmaeogeneties in Caucasian subjects[J]. Br J Clin Pharmacol, 1998, 46(2): 151-156.
  • 10贾莉,李建华,蔡剑平,郭健.汉族人群中二氢嘧啶脱氢酶基因多态性的初步研究[J].中日友好医院学报,2005,19(4):202-204. 被引量：13

二级参考文献14

  • 1Tuchman M,Stoeckeler JS,Kiang DT, et al. Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity[J].N Engl J Med, 1985,313:245-249.
  • 2Diasio RB,Beavers TL,Carpenter JT. Familial deficiency of dihydropyrimidine dehydrogenase biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity[J].J Clin Invest, 1988,81:47-51.
  • 3Harris BE, Carpenter JT, Diasio RB. Severe 5- fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency[J]. Cancer, 1991,68:499-501.
  • 4Wei X, McLeod HL, McMurrough J,et al. Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity[J].J Clin Invest, 1996,98:610-615.
  • 5Kouwaki M, Hamajima N, Sumi S,et al. Identification of novel mutations in the dihydropyrimidine dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity[J].Clin Cancer Res, 1998,4:2999-3004.
  • 6Vreken P, Van Kuilenburg ABP, Meinsma R,et al. Identification of novel point mutations in the dihydropyrimidine dehydrogenase gene[J]. J Inher Metab Dis, 1997,20:335-338.
  • 7Vreken P,Van Kuilenburg ABP,Meinsma R,et al. Identification of a four-base deletion (del TCAT296-299) in the dihydropyrimidine dehydrogenase gene with variable clinical expression[J].Hum Genet, 1997,100: 263-265.
  • 8Wei X, Elizondo G, Sapone A,et al. Characterization of the human dihydropyrimidine dehydrogenase gene[J]. Genomics,1998,51: 391-400.
  • 9Ridge SA,Sludden J,Wei X,et al. Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer[J]. Br J Cancer, 1998,77:497-500.
  • 10Ridge S A, Sludden J, Brown O,et al. Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects[J].Br J Clin Pharmacol,1998,46:151-156.

共引文献12

同被引文献56

  • 1兰蓉,朱兰,姚新荣,王鹏,邵庆勇,洪琼花.山羊产羔数全基因组关联分析[J].畜牧兽医学报,2015,46(4):549-554. 被引量：22
  • 2贾莉,李建华,蔡剑平,郭健.汉族人群中二氢嘧啶脱氢酶基因多态性的初步研究[J].中日友好医院学报,2005,19(4):202-204. 被引量：13
  • 3呼格吉乐图,旭日干.我国山羊业的发展现状及趋势分析[J].草食家畜,2005(4):1-8. 被引量：9
  • 4Allegra C J, Paik S, Colangelo LH, et al. Prognostic value of thymidylatesynthase,Ki-67 ,and p53 in patients with Dukes'B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study [ J ]. J Clin Oncol, 2003,21 (2) :241 -50.
  • 5Guimbaud R, Guichard S, Dusseau C, et al. Dihydropyrimidine dehydrogenase activity in normal, inflammatory and tumour tissues of colon and liver in humans[ J ]. Cancer Chemother Pharmacol 2000; 45(6) :477 -82.
  • 6Johnson MR, Wang K, Diasio RB. Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype[ J]. Clin Cancer Res,2002,8 (3) :768 - 74.
  • 7Lazar A, Jetter A. Pharmacogenetics in oncology:5-fluorouracil and the dihydropyrimidine dehydrogenase [ J ]. Dtsch Med Wochenschr. 2008,133(28 -29) :1501 -4.
  • 8Terashima M. Genetic polymorphisms related to fluoropyrimidine sensitivity and toxicity [ J ]. Gan To Kagaku Ryoho. 2008,35 ( 7 ) : 1101 -4.
  • 9Jvan Kuilenburg AB, Haasies J, Me Insma R, et al. Dihydropyrimidine dehydrogenase (DPD)deficiency:novel mutations in the DPD gene [ J]. Adv Exp Med Biol,2000,486:247 - 50.
  • 10Zhou ZW, Wang GQ, Wan DS, et al. The dihydrouracil/uracil ratios in plasma and toxicities of 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer patients [ J ]. Chemotherapy. 2007,53 ( 2 ) : 127 -31.

引证文献5

二级引证文献10

中国肿瘤
2008年 第12期

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