摘要
目的探讨N-端脑钠肽前体在慢性阻塞性肺疾病(COPD)中的变化及其意义。方法117例确诊为COPD患者,分为单纯COPD组和COPD合并肺心病组,用电化学发光法测定血浆NT-ProB-NP并比较其差异。结果COPD合并肺心病组NT-ProBNP水平明显高于单纯COPD组,且NT-ProBNP水平在轻、中、重度肺动脉高压组间差异有统计学意义(P<0.05);NT-ProBNP与肺动脉收缩压、主肺动脉宽度、右心室前壁厚度、右心室舒张末内径有良好的相关性。结论血浆NT-ProBNP浓度能较好地反映COPD患者的肺动脉高压情况及右心室功能状态。
Objective To study the change and the significance of N-terminal pro-brain natriuretic peptide in the COPD patients. Methods 117 COPD patients were selected and divided into the pure COPD group and the COPD with chronic pulmonary heart disease group . NT-ProBNP was measured by using electrochemiluminescence law and its difference was compared finally. Results NT-PreBNP in the COPD with chronic pulmonary heart disease group was higher than that in the pure COPD group （ P 〈 0. 01 ） ; group mild pulmo- nary hypertension, group moderate pulmonary hypertension and group sever pulmonary hypertension were compared in NT-ProBNP , three groups were significantly differences（ P 〈 0. 05 ）. NT-ProBNP was related positively to pulmonary arterial systolic pressure , aortopulmonary width , right ventricular anterior wall thickness and right ventricular end-diastolic diameter. Conclusion NT-ProBNP plays an important role in the diagnosis of chronic pulmonary heart disease and reflects the pulmonary hypertension and right ventricular function status in COPD.
出处
《中国实用医药》
2008年第33期31-33,共3页
China Practical Medicine
