摘要
目的:观察促性腺激素释放激素(GnRH)拮抗剂联合促性腺激素(Gn)进行超排卵(COH)的临床效果。方法:选取32例行体外授精-胚胎移植(IVF/ICSI)的患者,随机分为实验组(n=11)和对照组(n=21)。实验组应用GnRH拮抗剂抑制垂体,对照组应用GnRH激动剂垂体降调节,长方案。比较2组患者的卵巢刺激效果、种植率、妊娠率及妊娠结局。结果:2组取卵数、受精卵数、移植胚胎数、获得胚胎总数、冷冻胚胎数差异均无统计学意义(P均>0.05),卵巢刺激效果相同;2组种植率和妊娠率比较,差异亦无统计学意义(P均>0.05)。实验组无患者出现流产,对照组3例患者出现流产(P<0.05)。结论:GnRH拮抗剂能够取得与GnRH激动剂垂体降调节长方案超排卵相同的治疗效果。
Aim： To investigate the clinical effects of administration of gonadotrophin releasing hormone（GnRH） antagonist combined with gonadotrophin（Gn） for controlled ovarian hyperstimulation（COH） in patients treated with assisted reproduction technology（ART）.Methods：A total of 32 patients undergone in vitro fertilization（IVF） or intracytoplasmic sperm injection（ICSI） were randomly divided into two groups： study group（11 cases） and control group（21 cases）.The study group was received GnRH antagonist on pituitary down-regulation and the control group was received GnRH agonist on pituitary down-regulation,long protocol.The effects of ovarian stimulation,implantation rate,and pregnancy rate were observed.Results：There was no significant difference between two groups on the number of retrieved oocytes,fertilization rate,the number of embryo transplant,the total number of embryos,and frozen embryos（P〉0.05）.The two groups had equal effects on ovarian stimulation.There was no significant difference between two groups on the implantation rate and pregnancy rate（P〉0.05）.There was no case of miscarriage in the study group,but three cases occurred in the control group（P〈0.05）.Conclusion： The short GnRH antagonist and long GnRH agonist protocol on pituitary down-regulation have no difference among clinical effects on ovarian stimulation.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2008年第6期1192-1195,共4页
Journal of Zhengzhou University(Medical Sciences)
关键词
超排卵
促性腺激素释放激素拮抗剂
促性腺激素释放激素激动剂
促性腺激素
controlled ovarian hyperstimulation
gonadotrophin releasing hormone antagonist
gonadotrophin releasing hormone agonist
gonadotrophin
作者简介
女，45岁，硕士，副主任医师，研究方向：生殖医学
