摘要
目的:探讨缬沙坦治疗早期糖尿病肾病的作用。方法:采用随机对照研究早期糖尿病肾病患者240例,随机分为三组,每组80例,试验组给以缬沙坦及格华止治疗,对照第1组只给胰岛素,对照第2组只给格华止治疗,疗程6月。治疗前后测定各组患者尿微量白蛋白(MAU),空腹血糖(FPG),餐后2小时血糖(2PG),糖化血红蛋白(HbA1C),同时观察不良反应。结果:治疗后发现三组均有降糖作用;试验组与对照第1组有降低MAU作用(P<0·01),对照第2组无明显改变(P>0·05);其中对照第1组发生显著低血糖副作用。结论:缬沙坦联合格华止治疗早期糖尿病肾病有显著疗效且用药安全。
The aim is to assess the therapeutic effect of valsartan combined with metformin in patients with early diabetic nephropathy.The method applied：two hundreds forty patients with early diabetic nephropathy were randomly divided into experiment group treated with valsartan combined with metformin （n=80） and control group I treated with insulin （n=80） and control group II treated with metformin only （n=80） for 6 months.Microalbuminuria（MAU）,fasting plasma glucose（FPG）,two hour post plasma glucose（2hPG）,Hba1c were detected before and after treatment,respectively.Side-effects were also observed during the experiment.The result shows that the level of plasma glucose three in experiment group and control group were reduced at the end point compared with baseline,the level of MAU were obviously reduced in experiment group and control group number one （p〈0.01）,while the change was not obvious in the control group （P〉0.05）.Hypoglycemia side-effect occurred during the experiment in control group number one.Conclusion：Valsartan combined with metformin was an effective and safe remedy for early diabetic nephropathy.
出处
《华西医学》
CAS
2008年第3期583-584,共2页
West China Medical Journal
作者简介
姚秋生（1963-），男，四川西昌人，主治医师。
