期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脂类及脂蛋白与阿尔茨海默病 被引量：2

Role of lipids and lipid-associated proteins in Alzheimer's disease
在线阅读 下载PDF
导出
摘要 在阿尔茨海默病(AD)的病例中,散发型AD占很大部分,其主要临床特征是认知障碍。脂类及相关蛋白是造成散发型AD的重要危险因素之一。大量研究发现,胆固醇代谢、脂蛋白(a)、载脂蛋白ApoE等都与AD的发病和痴呆的发生有重要关联。 Sporadic Alzheimer＇s disease （AD） patients almost take up 95 % of the total AD pa tients. Plenty of researches suggest that a part of sporadic AD is mainly related to lipid and lipid--associ ated proteins, such as cholesterol, lipoprotein （a） and apolipoprotein E （ApoE）.
作者 刘婷婷 崔德华
机构地区 北京大学神经科学研究所神经生物国家重点学科教育部卫生部神经生物重点室验室
出处 《神经疾病与精神卫生》 2008年第5期329-334,共6页 Journal of Neuroscience and Mental Health
基金 国家自然基金(项目号30570553 30670414) 科技部973项目(2006CB500705)资助
关键词 阿尔茨海默病 脂类及相关蛋白 胆固醇 脂蛋白(a) APOE Alzheimer＇s disease （AD） Lipids Lipoprotein ApoE Cholesterol
分类号 R749.16 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献69

  • 1Dietschy JM, Turley SD. Cholesterol metabolism in the brain [J]. Curr Opin Lipidoh 2001,12 : 105-- 112.
  • 2Jurevics H, Morell P. Cholesterol for synthesis of myelin is made locally, not imported into brain[J].J Neurochem, 1995, 64:895 -901.
  • 3Lutjohann D, Bjorkhem I. Cholesterol homeostasis in human brain: evidence for an age dependent flux of 24S--hydroxycholesterol from the brain into the circulation[J]. Proc Natl Acad Sci USA,1996,93:9799- 9804.
  • 4Bjorkhem I, Wahren J. Cholesterol homeostasis in human brain: turnover of 24S--hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation[J]. J Lipid Res,1998,39:1 594--1 600.
  • 5Poirier J. Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease[J]. Neurobiol Aging,2005, 26:355 -361.
  • 6Simons M, Simons K. Cholesterol depletion inhibits the generation of beta amyloid in hippocampal neurons[J].Proc Natl Acad Sci USA,1998,95:6460 -6464.
  • 7Kojro E, Fahrenholz F. From the cover: low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha secretaseADAM 10[J]. Proc Natl Acad Sci USA,2001,98: 5 815--5 820.
  • 8Wahrle S, Golde TE. Cholesterol--dependent gamma secre tase activity in buoyant cholesterol -- rich membrane mi crodomains[J].Neurobiol Dis, 2002,9 : 11 -- 23.
  • 9Mori T, Mullan MJ. Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APPsw mice [J]. J Neuropathol Exp Neurol, 2001,60 : 778-- 785.
  • 10Mason RP, Herbette LG. Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol[J]. Neurobiol Aging, 1992,13 : 413-- 419.

同被引文献40

  • 1崔德华.脑衰老生物学[M]//寿天德.神经生物学.北京:高等教育出版社,2012:436-451.
  • 2Acosta-Baena N, Sepulveda-Falla D, Lopera-Gomez CM,et al. Pre-dementia clinical stages in presenilin 1 E280A fa- milial early-onset Alzheimer's disease: a retrospective cohort study[J]. Lancet Neurol,2011,10(3): 213-220.
  • 3Reiman EM, Quiroz YT, Fleisher AS, et al. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study[J]. Lancet Neurol, 2012,11(12):1 048-1 056.
  • 4Vanitallie TB. Preclinical sporadic Alzheimer's disease: target for personalized diagnosis and preventive intervention[J]. Me tabolism,2013,62 Suppl 1 ~$30-$33.
  • 5Li L, Yin Z, Liu J, ct al. CYP46A1 T/C polymorphism asso- ciated with the APOEe4 allele increases the risk of Alzhcimer's disease[J] J Neurol,2012.
  • 6Rodriguez- Rodriguez E, Vazquez- Higuera JL, Sanchez- Juan P, et al. Epistasis between intracellular cholesterol traf- ficking- related genes (NPC1 and ABCA1) and Alzheimer's disease risk[J]. J Alzheimers Dis,2010,21(2) :619-625.
  • 7Martiskainen H, Haapasalo A, Kurkinen KM, et al. Targe- ting ApoE4/ApoE receptor LRP1 in Alzheimer's disease[J]. Expert Opin Ther Targets,2013.
  • 8Jick H, Zornberg GL, Jick SS, et al. Statins and the risk of dementia[J] Lancet,2000,356(9 242) :1627-1631.
  • 9Sparks DL, Seheff SW, Hunsaker JC 3rd, et al. Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol[J]. Exp Neurol, 1994,126 (1) :88-94.
  • 10Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiologi- cal and preelinical studies [J]. Arch Neurol, 2011,68 (10) 1 239-1 244.

引证文献2

二级引证文献4

神经疾病与精神卫生
2008年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
关于我们 | 版权声明 | 联系我们 | 帮助中心| 意见反馈
主办单位：上海市教育委员会
技术支持：重庆维普资讯有限公司
渝公网安备 50019002500403号
使用帮助 返回顶部