摘要
目的:观察凋亡调节蛋白的表达与脑膜瘤级别、复发的关系。方法:用LSAB免疫组织化学方法对80例脑膜瘤细胞中凋亡调节蛋白BCL-2、Bax和Bcl-XL的表达进行分析。结果:恶性组BCL-2瘤蛋白阳性率(88%)明显高于良性组(37%)(P<0.05)。分别比较良性组、非典型组和恶性组中Bax、BCL-XL癌蛋白表达阳性率,无显著差异(P>0.05)。而BCL-2+BCL-XL/Bax与脑膜瘤级别有统计学相关性(P<0.01)。非复发组、复发组首次手术组、再次复发组中BCL-2、Bax和Bcl-XL癌蛋白阳性率两两比较均无显著性差异(P>0.05)。结论:BCL-2、Bax和Bcl-XL在脑膜瘤发生中起调节作用,BCL-2+BCL-XL/Bax是脑膜瘤生物学行为的有效检测法。
Objective： To explore the relationship between expression of apoptosis-modulating proteins and histopathological grade and recurrence in meningioma. Methods： Immunohistochemistry method （LSAB） was used to detect the expression of BCL-2, Bax and BcI-XL, in 80 cases of meningioma including benign group （38cases）, atypical group （26cases） and malignant group（16cases）. 48 cases of selected whole materials were classified as recurrence （16 cases） and non-recurrence （22 cases）. Results： Expression of BCL 2 oncoprotein positive in malignant group （88%） was significantly higher than benign group （37%） （P〈0.05）. The expression of Bax and BCL XL oncoprotein positive in benign, atypical and maligant rneningiomas were not significant different （P〉0.05）. But BCL-2＋ BCL-XL/Bax was associated statistically with meningioma grade （P〈0.01）. The expression of BCL-2 and Bax,BCL-XL oncoprotein positive in non-recurrent, initially resected recurrent and recurrent meningiomas, were not significant differenl （P〉0.05）. Conclusion： BCL-2, Bax and Bcl-XL might play important roles in meningioma and BCL-2 ＋ BCL-XL/Bax was useful parameters for estimating of biological behavior of meningiomas.
出处
《中国临床医学》
北大核心
2008年第5期719-720,共2页
Chinese Journal of Clinical Medicine
关键词
脑膜瘤
生物学行为
凋亡调节蛋白
免疫组织化学
Meningioma
Biological behavior
Apoptosis-modulating proteins
Immunohistochemistry
