摘要
F-box蛋白是一类广泛存在于真核生物中,含有F-box结构域的蛋白家族,在泛素-蛋白酶体途径(ubiquitin-protcasomc pathway,UPP)中因特异识别底物蛋白而参与细胞周期调控、转录调控、细胞凋亡、细胞信号转导等生命活动。另外,F-box蛋白还通过其他作用方式参与了体内众多生化过程。本文综述了F-box蛋白的结构和作用途径,以及该蛋白参与的多种生理功能,展示了F-box蛋白家族在生命活动中具有广泛而重要的作用,并指出了F-box蛋白将为阐明疾病发生机制提供新的线索,可望成为疾病治疗中药物作用的靶向位点。
F-box proteins are an expanding family of eukaryotic proteins characterized by an ＂F-box＂ motif. They are in charge of substrate specificity in the ubiquitin-proteasome pathway and therefore play a pivotal role in many physiological activities such as cell-cycle progression, transcriptional regulation, programmed cell death and cell signal transduction. In addition, F-box proteins participate in many other biochemical processes through different ways. In this review we focus on the structure and function of F-box proteins and reveal that this protein family has an important role in life. Furthermore, we indicate that F-box proteins are attractive candidates in the disease therapy and drug interaction.
出处
《生命科学》
CSCD
2008年第5期807-811,共5页
Chinese Bulletin of Life Sciences
基金
福建省青年科技人才创新项目(2006F3128)
作者简介
通讯作者：孙莉萍，E-mail：sunliping@xmu．edu．cn
通讯作者：张其清，E-mail：zhangqiq@xmu．edu．cn；
