摘要
目的:探讨急性冠脉综合征(ACS)患者血基质金属蛋白酶(MMP)2和9含量的变化及其培哚普利的的干预影响。方法:选择60例健康人做对照,60例ACS患者随机被分为常规治疗组(n=30例)和培哚普利治疗组(n=30例),治疗3周,治疗前、后测量血清MMP-2和MMP-9含量的变化。结果:ACS患者血清MMP-2,9含量显著高于健康对照组(P<0.01);培哚普利组血清MMP-9含量显著低于常规治疗组(P<0.05)。结论:培哚普利能够抑制基质金属蛋白酶9的分泌。
Objective.. To investigate the effects of perindopril on serum level of metric metalloprotease--2 （MMP--2） and metalloprotease-- 9 （MMP-- 9） in patients with acute coronary syndromes （ACS）. Methods.. The 60 healthy people were selected as the control group, 60 ACS patients were randomly divided into two groups： conventional therapy group （n= 30）, perindopril group （treated with perindopril on the basis of convectional therapy for three weeks, n ： 30）; Before and after treatment the serum level of MMP--2 and MMP--9 were detected. Results： The serum level of MMP--2 and MMP--9 in ACS group was higher than those of healthy control group （P〈0.01） . After treatment, the serum level of MMP--2 and MMP--9 in perindopril group significantly decreased （P〈0.05） and the MMP --9 level decreased more than that of control group （P〈0.05）. Conclusion： Perindopril can decreases the biosynthesis of MMP--9 .
出处
《心血管康复医学杂志》
CAS
2008年第5期490-492,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
