摘要
目的:对早期以植物神经功能障碍(AD)为首发的格林巴利综合征(GBS)患者进行研究,并与非AD首发的患者进行对比,观察其发病形式、病情的轻重程度及其预后,并探讨脑脊液蛋白含量与病情转归的关系。方法:采用病例对照研究,对符合诊断的99例患者病情进行分析,并对AD首发及非首发的患者的临床表现、病情轻重程度、病情转归及脑脊液蛋白含量进行对比、分析。结果:以AD首发的患者在发病1周后病情严重程度明显高于对照组(P<0.05),其发病三周后病情转归亦明显差于对照组(P<0.05),AD首发的患者病情转归中为显效、好转、无效的患者在发病2周时脑脊液蛋白含量明显高于对照组(均P<0.05),两组患者病情转归愈差其脑脊液蛋白愈高(P<0.05)。结论:以AD首发的GBS患者,其病情严重程度、预后均较非AD首发的患者差,发病2周时的脑脊液蛋白含量可作为判断患者预后的辅助指标。
Objective To study the patients with acute Guillian -Barre （GBS） syndrome whose early symptom represent autonomic dysfunction and to contrast with the patients without autonomic dysfunction. To observe the form of illness,the degree of illness strictness and the prognose . To discuss the relation of cerebrospinal fluid albumen content and the prognose of illness. Methods To adopt case control study and analysis the illness state of ninety - nine patients whose illness accord with diagnosis. The clinic representation , the degree of illness strictness , the illness prognose and the eerebrospinal fluid albumen content were contrasted and analysised between AD group and control group. Results The degree of illness strictness of AD group were obviously higher than that of the control group after a week of illness（ P 〈 0.05 ）. The illness prognose after three weeks of illness were obviously worse than that of the control group （ P 〈 0.05 ）. The cerebrospinal fluid albumen content whose illness prognose were significant, improved and ineffective in AD group were obviously higher than that of the control group at the second week after illness（ P 〈0.05）. The worse the illness prognose was,the higher the cerebrospinal fluid albumen con- tent was（ P 〈 0.05 ）. Conclusion The degree of illness strictness and the illness prognose of AD group patients with GBS were worse t.han that of the control group. The cerebrospinal fluid albumen content at the second week after illness can be a assistant guideline to estimate the prognose of the patients.
出处
《实用医技杂志》
2008年第31期4360-4362,共3页
Journal of Practical Medical Techniques
关键词
格林巴利综合征
植物神经
功能障碍
Guillain - Barre syndrome
Aulonomic nervous
Dysfunction
