摘要
目的观察甲氨蝶呤(MTX)以不同给药方法治疗未破裂型异位妊娠的疗效。方法回顾性分析2004年1月～2006年12月于该院住院治疗符合药物保守治疗条件的异位妊娠98例患者分为3组:A组:MTX(50mg/m2)单次肌内注射,B组:MTX(50mg/m2)单次肌内注射并口服米非司酮,C组:MTX(50mg/m2)单次肌内注射并口服活血化淤中药,分别于治疗前及后第4日起每隔3日检测血β-HCG,每周复查盆腔超声,同时观察有无MTX药物副反应出现。结果98例应用MTX治疗的异位妊娠,治疗过程中因腹腔内出血改行手术治疗的15例,占15.5%,保守治疗总体成功率84.5%,3组成功率分别为:A组80.0%,B组84.0%,C组86.0%差异无显著性(P>0.05);B、C两组较A组明显缩短血β-HCG降至正常所需的时间,减少住院日(P<0.01),B、C两组间差异无显著性(P>0.05),但C组副反应明显比B组少(P<0.01)。结论MTX单次肌内注射联合中药治疗异位妊娠疗效好、副反应少,值得临床推广。
[Objective] To evaluate MTX＇s effects on unruptured ectopic pregnancy, which MTX is used in different methods.[Method] 98 patients which are admitted to our hospital from 2002 to 2007 are conserved treatment in retrospective analysis. These patients are arranged to three groups MTX （50 mg/m^2） in simple muscular injection, MTX （50 mg/m^2） combined with RU486; MTX （50 mg/m^2） plus Chinese herb （invigorate the circulation of blood and eliminate gore） orally. We measured the β-HCG pretreatment and over 3 days from the 4 day, and also B ultrasound is checked by every week, and observed the MTX side-effects. [Results] MTX is used to 98 eases ectopie pregnancy, in the course of the treatment, the 15 patients is reversed to laprotomy for intraabdominal bleeding, it accounts for 15.5%, The total successful rate in conservative treatment is 84.5%, the successful rate in 3 groups is 80%, 84%, 86% respectively, there is no significant difference （P〉0.05）. The time which β-HCG is decent to normal in B and C group is obviously shorted compared to A group, decreased the admitted duration （P 〈0.01）, there is no sig- nificant difference （P 〉0.05）, but side effect in C group is obviously lessened in B group （P 〈0.01）. [Conclusion] There has good effect that MTX combined with herb and there is little side effect. It is worthwhile clinically popularizing.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第19期2880-2882,共3页
China Journal of Modern Medicine
关键词
异位妊娠
保守治疗
甲氨蝶呤
ectopic pregnancy
conservative therapy
MTX
