摘要
目的:探讨芒果苷片薄膜包衣工艺的最佳工艺参数。方法:采用比较法和正交试验设计法,以包衣片外观合格率、硬度、增重、耐湿度、溶出度等作为考核指标,确定薄膜包衣的最佳工艺参数。结果:最佳包衣工艺参数为:包衣液浓度为13%,主机转速为12 r·min^(-1),片床温度45℃。结论:此工艺稳定可行。
Objective： To optimize the conditions of thin-film coating process for mangiferin tablets. Methods： The evaluation indexes were appearance qualified rate, hardness, weight increment, humidity endurance, and dissolution rate. Thin-film coating process conditions were optimized by compare-method and orthogonal method. Results： The best process parameters were that concentration of coated solution was 13%, engine speed was 12r·min^-1, and bed temperature was 45℃. Conclusion： The process was feasible and stable.
出处
《中国药师》
CAS
2008年第10期1140-1142,共3页
China Pharmacist
基金
国家科技部"西部开发"重大项目(2004BA901A09)
广西科技攻关项目(桂科攻关0592001-13)
关键词
芒果苷片
薄膜包衣工艺
比较法
正交设计法
Mangiferin tablet
Thin-film coating process
Compare-method
Orthogonal method
作者简介
邓家刚，男，教授，博士生导师。研究方向：中药药性理论与中药药效筛选研究。Tel：0771—3137555，013607715699 E-mail：dengjg@tom．com
通讯作者：王志萍，女，副教授，硕士生导师。研究方向：中药制剂工艺研究。Tel：0771-2219857，013878818902 E-mail：gxwangping@yahoo．com.cn
