摘要
Novel water-soluble amphiphilic ternary graft copolymers(COS-g-PCL-b-MPEG) were synthesized by N,N′-dicyclohexyl carbodiimide(DCC) coupling reaction between chitooligosaccharide(COS) with MPEG-b-PCL-COOH,which was synthesized via ring-opening polymerization of ε-caprolactone(CL) with methoxy poly(ethylene glycol)(MPEG) as an initiator and subsequent carboxylation by succinic anhydride.The che-mical composition of the graft copolymers was studied by 1H NMR spectrum.In aqueous solutions,stable supramolecular hydrogels could be rapidly fabricated via the inclusion compound between the MPEG-b-PCL graft of COS derivates and α-CD.The supramolecular structure of the hydrogels was revealed by WXRD analysis.The temperature sweep test results show that no gel-sol transition temperature appears over the range from 20 ℃ to 60 ℃ for the obtained hydrogels.
Novel water-soluble amphiphilie ternary graft copolymers （COS-g-PCL-b-MPEG） were synthesized by N, N＇-dicyclohexyl carbodiimide （DCC） coupling reaction between chitooligosaccharide （COS） with MPEG- b-PCL-COOH, which was synthesized via ring-opening polymerization of ε-caprolactone （CL） with methoxy poly（ethylene glycol）（MPEG） as an initiator and subsequent carboxylation by succinic anhydride. The chemical composition of the graft copolymers was studied by ^1H NMR spectrum. In aqueous solutions, stable supramolecular hydrogels could be rapidly fabricated via the inclusion compound between the MPEG-b-PCL graft of COS derivates and α-CD. The supramolecular structure of the hydrogels was revealed by WXRD analysis. The temperature sweep test results show that no gel-sol transition temperature appears over the range from 20 ℃ to 60 ℃ for the obtained hydrogels.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2008年第9期1914-1916,共3页
Chemical Journal of Chinese Universities
基金
湖北省青年杰出人才基金(批准号:2007ABB033)资助
关键词
三元接枝共聚物
偶联反应
包合作用
超分子水凝胶
Ternary graft copolymer
Coupling reaction
Inclusion compound
Supramolecular hydrogel
作者简介
联系人简介：赵三平，男，副教授，主要从事可降解高分子材料合成．E-mail：zhaosanping@163．com
