摘要
目的通过对感染性心内膜炎(IE)患者病原菌及其耐药率的分析,探讨IE病原菌的变迁及抗菌药物的合理应用情况。方法对1997年1月至2006年12月收治的207例IE患者的病原菌情况进行回顾性分析,按住院时间分为Ⅰ组(2002年1月至2006年12月)及Ⅱ组(1997年1月至2001年12月),其中Ⅰ组77例,Ⅱ组130例。结果血细菌培养阳性率47.83%,其中Ⅰ、Ⅱ组阳性率分别为38.96%和53.08%。链球菌在致病菌中的比例亦由Ⅱ组的52.17%下降到Ⅰ组的33.33%。而金黄色葡萄球菌的比例则由15.94%上升到23.33%。链球菌对青霉素G耐药率低,但近年来已由19.44%上升到30.00%。结论血细菌培养阳性率近年来有所下降,链球菌仍然是IE的主要病原菌,对青霉素G耐药率较低,但近年来已有所上升。金黄色葡萄球菌的比例则上升。
Objective Through the analysis of the pathogenic bacteria isolated from patients with infective endocarditis （IE）, to explore the changes of the pathogenic bacteria isolated from IE patients and the reasonable use of antibiotics. Methods The pathogenic bacteria isolated from 207 hospitalized IE patients between January 1997 and December 2006 were identified and characterized. They were divided into two groups according to their date of admission. Group Ⅰ including 77 patients admitted from January 2002 to December 2006, and group Ⅱ including 130 cases admitted from January 1997 to December 2001. Results During the past 10 years, positive blood germicuhure rate of all cases was 47.83% and significantly decreased from 53.08% （group Ⅱ ） to 38.96% （group Ⅰ ）. The ratio of Streptococcus reduced from 52.17% （group Ⅱ ） to 33.33% （group Ⅰ ）, while the ratio of Staphylococcus aureus increased from 15.94% to 23.33%. The rate of drug tolerance to penicillin in Streptococcus was low and increased from 19.44% to 30.00%. Conclusion During the past 10 years, positive blood germieuhure rate was descending. Streptococcus still was the main pathogenic bacteria. Its rate of drug tolerance to penicillin was low, increased nevertheless. Staphylococcus aureus infection was increased in IE patients.
出处
《热带医学杂志》
CAS
2008年第9期911-914,共4页
Journal of Tropical Medicine
基金
国家杰出青年科学基金(No.30525020)。
关键词
心内膜炎/感染性
病原菌
耐药性
endocarditis/infective
pathogenic bacteria
drug tolerance
作者简介
陈光献（1975-），男，畲族，主治医师，博士生，研究方向为心脏外科。
通讯作者：吴钟凯（1967-），男，汉族，教授，医学博士，E—mail：wuzhongkai@hotmail．com
