摘要
以层状复合氢氧化物(LDH)为载体用离子交换法制取乙酰苯甲酸(ASP)的插层复合物LDH-ASP,通过体外释放实验和固相XRD、FT-IR、TEM、TG-DSC及BET-N2比表面积表征,研究了药物释放环境对载体结构的影响.结果表明释放环境pH为4.30-6.89时,载体的层状特征减弱但晶体类型不变;pH为2.48-4.30时,H2PO4-对LDH的嫁接反应引起层状化合物向复杂磷酸盐转化;随环境pH由6.89降低至2.48,载体纯度下降,晶态性征减弱,微孔吸附活性降低.
Layered double hydroxide （LDH） had been used as a cartier of acetylsalicylic acid （ASP） to prepare intercalation compound LDH-ASP via ion exchange reaction. The influence of release medium on the carrier was investigated through extrinsic release test and XRD, FT-IR, TEM, TG-DSC, and BET-N2 surface area characterizations. The results showed that the carder＇s laminar features weakened in a pH range from 4.30 to 6.89, but the LDH crystalclass kept unchanged. In a pH range from 2.48 to 4.30, the probable grating reaction between H2PO4^- and hydroxyls of LDH caused laminar carder transformation into complex phosphates. Along with pH decreased from 6.89 to 2.48, the carrier＇s purity decreased, crystallinity weakened, and micro-pore absorbability declined.
出处
《物理化学学报》
SCIE
CAS
CSCD
北大核心
2008年第9期1675-1680,共6页
Acta Physico-Chimica Sinica
基金
教育部科学技术研究重点项目基金(207127)
宁夏自然科学基金(NZ0659)
宁夏高等学校科学技术研究基金(JC200518)资助
关键词
药物释放环境
LDH-ASP复合物
晶型转化
控释载体
Drug release medium
LDH-ASP intercalation compound
Crystal change
Controlled-release carrier
作者简介
Corresponding author．Email：ggi64@yahoo．com．cn；Tel：＋86013895652708．
