摘要
宫颈癌的发生与高危型人乳头瘤病毒(human papillomavirus,HPV)感染高度相关已得到公认。利用基因重组技术开发HPV疫苗是目前预防宫颈癌唯一有效的方法。综述了近年来在基因工程HPV疫苗研制中广泛应用的载体表达系统及其特点,依据密码子偏爱原则优化病毒外壳蛋白基因序列显著提高外壳蛋白产量等方面的研究成果,以为进一步研制与优化HPV疫苗提供参考。
It＇ s commonly accepted that the infection of HPV with high-risk is the important factor in the occurrence of cervix cancer. Recombinate technologies are used to develop HPV vaccines, which is the only effective method to prevent cervix cancer so far. From the both aspects of expression vectors and codon optimization, this article reviewed the widely used expression vectors in recent years and their characteristics;As well as the research results on obviously enhancement of capsid protein by optimizing the virus capsid gene according to codon preference, which provide basis for the further manufacturing and optimization of HPV vaccines.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2008年第9期130-134,共5页
China Biotechnology
关键词
HPV
疫苗
表达系统
密码子优化
HPV Vaccines Vector expression system Codon modification
作者简介
通讯作者，电子信箱：xiahz612@sina．com
