摘要
目的:探讨应用羟基磷灰石/甲基丙烯酸甲酯(HA/PMMA)骨水泥行颈椎椎体成形后椎体抗压缩力和刚度的变化情况。方法:3具成年男性新鲜尸体颈椎C4～C6标本,解离成9个脊椎节段标本,去除所有软组织,切除脊椎后部结构,仅剩下椎体部分,在MTS试验机上以5mm/min的加载速率加载椎体中心处,压缩3mm或椎体负载压力出现下降时记录压缩力、最大压缩力、最大压缩力的位移和刚度。自椎体前正中用11G的骨穿针刺入椎体1～1.5cm,注射10%HA/PMMA骨水泥2ml,固化2h后再次行压缩测试,记录在位移3mm时的压缩力、最大压缩力、最大压缩力的位移和刚度。采用配对t检验比较两种状态的数据。结果:抗压力初始/成形后平均数值为1051.8/2033N,最大抗压力1237.2/2774.3N,最大压力位移3.42/4.13mm,刚度405.8/1274.2N/mm。成形后刚度和抗压缩力明显增强。成形后椎体负载的最大抗压力增大到约2.2倍,在压缩3mm时压力最大到约1.9倍,刚度增加到3.1倍,同时达到最大压力的位移也平均增加0.71mm。没有发现渗漏现象。结论:注射2mlHA/PMMA骨水泥对颈椎体成形后可明显增强其抗压缩力和刚度。
Objective： To determine the strength and stiffness of cervical vertebral compression fractures stabilized via anterior injection of 10% hydroxyapatite/polymethylmethacrylate（HA/PMMA） cement.Method：9 vertebral bodies（C4-C6） of three fresh spines were harvested from adult male cadavers,which were disartieulated,and loaded with axial compression in 5mm/min by MTS 858 materials testing machine to determine initial strength and stiffness.The vertebral bodies were compressed in every 3mm until the loaded pressure of the vertebral bodies decreased.Vertebroplasty was performed by injecting 2ml of 10% HA/PMMA into the center of vertebral bodies,then the bodies were recrushed to determine their strength and stiffness values.The strength at 3mm,the maximum strength,and displacement and stiffness in the maximum strength were recorded respectively.The data was studied by paired t test.Result：The average,maximum strength,displacement for maximum strength and stiffness of vertebral body in initial state and post-vertebroplasty were 1051.8/2033N, 1237.2/2774.3N,3.42/4.13mm,405.8/1274.2N/mm respectively.The strength and stiffness after vertebroplasty was markedly increased.The maximum strength increased to 2.2 fold with 1.9 fold of the axial compression pressure loaded at 3mm,meanwhile the displacement for maximum strength increased 0.71mm averagely,stiffness increased 3.1 fold.There was no bone cement leakage found.Conclusion：The cervical vertebral body augmentated with 2ml of 10% HA/PMMA for vertebroplasty results in increase of both strength and stiffness compared with the initial state.
出处
《中国脊柱脊髓杂志》
CAS
CSCD
2008年第9期677-679,共3页
Chinese Journal of Spine and Spinal Cord
关键词
椎体成形术
甲基丙烯酸甲酯
羟基磷灰石
骨水泥
颈椎
Vertebroplasty
Polymethylmethacrylate
Cervical vertebra
Hydroxyapatite
Bone cement
作者简介
第一作者：男（1967-），医学博士，副主任医师、研究方向：脊柱脊髓损伤电话：（010）66356729—2089 E—mail：doewjg@163．com
