摘要
目的探讨精神分裂症患者的认知功能及其与精神症状的相关性。方法入组31例精神分裂症患者及31例正常对照者,进行持续操作测验(CPT)、威斯康星卡片分类测验(WSCT)、Stroop色词测验、可反复测查的成套神经心理状态评估工具(RBANS)以及阳性与阴性症状量表(PANSS)评定,对心理测查成绩与精神症状指征进行相关性分析。结果精神分裂症患者组与正常对照组相比,除Stroop色词测验中卡片A(字)、B(色)、C(字色)错误数无明显差异外,各项心理测查指标均明显下降(P<0.05)。多项心理测查成绩,包括CPT测验中正确反应时、WSCT测验中随机错误数、Stroop色词测验中字义干扰时和颜色干扰时、RBANS测验总分和即刻记忆分,与PANSS部分症状评分显著相关(P<0.05)。结论精神分裂症患者记忆、注意、执行及言语功能受损。精神分裂症患者部分认知功能与精神症状显著相关。
Objective To evaluate the cognitive function and its correlation with psychiatric symptoms in patients with schizophrenia. Methods Thirty-one patients with schizophrenia and thirty-one healthy person as control were evaluated by neuropsychological test, such as continuous performance test （ CPT）, wisconsin card sorting test （WSCT） , stroop color-word test and repeatable battery for the assessment of neuropsychological status（RBANS） , and the positive and negative syndrome scale（PANSS） in schizophrenic patients. Results The scores in all items of neuropsychological test except the A, B, C wrong numbers of Stroop color- word test in schizophrenic patients were significantly poorer than those in healthy controls （ P 〈 0.05 ）. The correct time in CPT, the random wrong number in WSCT, word interference time and color interference time in Stroop color-word test, immediate memory score and total score in RBANS were significantly correlated with part of the scores in PANSS（P 〈 0.05）. Conclusion The memory, attention, executive performance and verbal function were impaired, and some cognitive function scores were significantly correlated with the psychiatric symptoms in patients with schizophrenia.
出处
《首都医科大学学报》
CAS
2008年第4期423-427,共5页
Journal of Capital Medical University
基金
北京市科委基金(2003BA712A11-04)资助项目~~
关键词
精神分裂症
认知功能
精神症状
schizophrenia
cognitive function
psychiatric symptoms
作者简介
Corresponding aulhor, E-mail： zhoudf@bjmu. edu. cn
