摘要
用2-苯基-1,2,3-三唑基-4-甲醛、喹喔啉基-2-甲醛和2-(4-溴苯基)-1,2,3-三唑基-4-甲醛为原料,在冰醋酸的条件下分别与二胺反应,合成了一系列新的双席夫碱5a～5d,6a～6d和7a～7d.目标化合物的结构经元素分析,IR,1HNMR,MS,X射线确证.同时测定了化合物6c的晶体结构.其属于单斜晶系,C2/c空间群,晶胞参数a=1.7670(4)nm,b=0.48001(10)nm,c=1.1751(2)nm,α=90.00°,β=94.42(3)°,γ=90.00°,V=0.9937(4)nm3,Dc=1.399g/cm3,Z=2,F(000)=436,μ=0.089mm-1,R=0.0413,wR=0.1067.初步生物活性筛选结果表明,目标化合物6b在Vero细胞上有抗疱疹病毒I型活性.
Condensation of diamines with 2-phenyl-1,2,3-triazole-4-carboxaldehyde, quinoxaline-2-carboxaldehyde or 2-（4-bromophenyl）-1,2,3-triazole-4-carboxaldehyde in the presence of glacial acetic acid gave a series of new bis-Schiff bases 5a-5d, 6a-6d and 7a-7d. The structures of new compounds were confirmed by elemental analysis, IR, ^1H NMR, mass spectra and X-ary diffraction methods. The crystal of the compound 6c belongs to monoclinic, space group C2/c with cell parameters α=1.7670（4） nm, b= 0.48001（10） nm, c=1.1751（2） nm, α=90.00°, β=94.42（3）°, γ=90.00°, V=0.9937（4） nm^3, Dc=1.399 g/cm^3, Z=2, F（000）=436, μ=0.089 mm^-1, R=0.0413, wR=0.1067. The preliminary biological activity tests show that the compound 6b has antiherpes virus type I activity toward Vero cells.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2008年第8期1423-1427,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20562011)
新疆大学青年教师启动基金资助项目
作者简介
E-mail： xiezhf72@yahoo.com.cn
E-mail： fmliu859@sohu.com
