摘要
目的评价鼻塞式持续气道正压通气(NCPAP)联合肺表面活性物质(猪肺磷脂注射液,固尔苏)对新生儿呼吸窘迫综合征(NRDS)的治疗作用。方法27例NRDS的患儿经气管滴入固尔苏[100mg/(kg.次)],然后拔管予NC-PAP呼吸支持治疗,作为NCPAP组。25例常规机械通气病例作为对照组(VT组),比较两组患儿的临床症状体征、血气变化、并发症、住院时间以及住院费用。结果治疗后1h,两组患儿症状体征明显好转;6h、12h及24h,两组患儿的血气较治疗前显著改善,两组比较,无明显差异;NCPAP组肺部感染及慢性肺部疾病的发生率明显低于VT组;NCPAP组的氧疗及住院时间明显少于VT组,住院费用也较低。结论NCPAP及固尔苏联合应用能有效地治疗NRDS,与常规机械通气比较,具有肺部感染、慢性肺部疾病发生率低、住院时间短、住院费用少等特点。
Objective To evaluate the curative effect of NCPAP combined with pulmonary surfactant （Curosurf） in treatment of neonatal respiratory distress syndrome. Methods Twenty seven cases of respiratory distress syndrome were administrated with NCPAP after intratracheal instillation of Curosurf [ 100 mg/（ kg· dose） ] （ NCPAP group）. Twenty five cases treated with conventional ventilation combined with pulmonary surfactant served as control group. Blood gas analysis, incidence of complications, hospitalization time and cost were compared between these two groups. Results Findings of blood gas analysis were improved at the time of 6, 12, 24 hours after treatment in these two groups. There was no significant difference between them. The babies in NCPAP group had significantly lower incidence of pulmonary infections and chronic lung diseases, less duration of oxygen inhalation and hospitalization time, and their charges were lower than those of control group. There was significant differenee between these two groups. Conclusion In preterm infants with respiratory distress syndrome, their prognosis can be improved by NCPAP combined with pulmonary surfaetant, and this regimen for treatment has the advantages of less pulmonary infections and chronic lung diseases, shorter duration of oxygen inhalation and hospitalization time and lower eharges.
出处
《临床和实验医学杂志》
2008年第8期25-26,共2页
Journal of Clinical and Experimental Medicine
关键词
NCPAP
肺表面活性物质
NRDS
机械通气
NCPAP
Conventional ventilation
Respiratory disease syndrome
Pulmonary surfaetant
