摘要
目的:探讨Prohibitin在胃黏膜组织中表达及其与胃癌临床病理特征的关系。方法:胃黏膜组织标本103例,其中胃癌60例,胃癌前病变25例,胃黏膜良性病变18例。采用免疫组织化学方法检测各种组织中Prohibitin的蛋白表达,并分析Prohibitin的表达与胃癌及各种临床病理特征的关系。结果:各类胃黏膜病变组Prohibitin阳性信号位于细胞浆内,在胃黏膜中多分布于黏膜腺体底部细胞;在胃癌组织中分布主要见于腺体结构尚完整的部位,部分癌细胞有阳性表达。胃癌组、癌前病变组及胃黏膜良性病变组Prohibitin阳性率分别为68.33%(41/60)、88.00%(22/25)和88.89%(16/18)。胃黏膜良性病变组Prohibitin阳性率明显高于胃癌组(P=0.006),而癌前病变组与胃黏膜良性病变组的阳性率比较差异无显著性(P=0.232)。结论:胃黏膜良性病变、癌前病变及胃癌发生段存在着Prohibitin蛋白表达的变化,提示检测胃黏膜病变组织中Prohibitin的表达对胃癌的诊断具有重要的临床价值。
Objective To investigate the expression of Prohibitin as well as its correlation with the pathological characteristics of gastric cancer （GC）. Methods Immunohistochemistry was used to detect the expression of Prohibitin in 103 cases of mucous membrane, 60 cases of gastric cancer, 25 cases of lesion precancerous, 18 cases of benign lesion. The correlations between Prohibitin expression and the clinical, pathological characteristics were analyzed by statistical method. Results The positive expression of Prohibitin in gastric mucosa lesion was in cytoplasm and mostly located in ceils at the bottom of gland body. But in gastric cancer, it was found in region with incomplete structure. The expression positive rates of Prohibitin in gastric cancer, precancerous lesion and benign lesion were 68.33% （41/60）, 88.00% （22/25） and 88.89%（16/18） separately. The expression of Prohibitin was significantly higher in benign lesion than that in gastric cancer （P=0. 006）, but there was no difference in the expression of Prohibitin between benign lesion and precancerous lesion （P= 0. 232）. The expression of Prohibitin had no marked correlation with the degree of differentiation. Conclusion The Prohibitin has different expressions during the developing of gastric cancer. It is showed that the detection of Prohibitin protein in gastric lesion tissue has the chinical value for diagnosis of gastric cancer.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2008年第4期649-652,共4页
Journal of Jilin University：Medicine Edition
基金
国家自然科学基金资助课题(30640072)
河南省高等学校创新人才培养工程资助课题(2005)
作者简介
冯云霞（1980-），女，河南省鄢陵县人，医学硕士，主要从事肿瘤流行病学研究。
[通讯作者]王凯娟（Tel：0371-67781393，E-mail：kjwang@163．com）
