摘要
目的探讨人涎液和胃液中表皮生长因子（ｈＥＧＦ）水平与消化性溃疡（ＰＵ）的关系．方法应用放免分析（ＲＩＡ）药盒，检测消化性溃疡８４例，慢性胃炎６５例和正常人２０例的涎液和胃液中的ｈＥＧＦ含量．结果消化性溃疡患者的ｈＥＧＦ（μｇ／Ｌ）在涎液（２１０±０９８及２１０±１０７）、胃液（１２５±０９９及１１８±０６３）均显著低于正常对照组（涎液２７４±１３１、胃液１８１±０９０）和慢性胃炎组（涎液２５７±１５４、胃液１５９±１３５）（Ｐ＜００５），活动期（Ａ期）消化性溃疡患者涎液中ｈＥＧＦ含量明显低于愈合期（Ｓ期）的患者（Ｐ＜００５）．结论测定涎液ｈＥＧＦ水平有助于对消化性溃疡患者的诊断和治疗．
IM To study the levels of human epidermal growth factor (hEGF) of gastric juice and saliva in patients with peptic ulcer(PU). METHODS The hEGF levels of gastric juice and saliva were determined using radioimmunoassay in 20 healthy subjects, 65 cases of chronic gastritis and 84 cases of peptic ulcers. RESULTS The hEGF concentrations (μg/L) of saliva in patients with gastric ulcer (GU) and duodenal ulcer (DU) were 210±098 and 210±107, respectively and of gastric juice were 125±099 and 118±063, respectively, lower than that in healthy volunteers (n=20,274±131 and 181±090, respectively) (P<005) and chronic gastritis (n=65, 257±154 and 159±135, respectively) (P<005). The hEGF concentration of saliva in patients with active peptic ulcer was lower than that in scar stage (P<005). CONCLUSION hEGF levels in saliva can be used in diagnosis and treatment of peptic ulcer.
关键词
消化性溃疡
涎液
胃液
表皮生长因子
peptic ulcer/metabolism
saliva/chemistry
gastric juice/chemistry
epidermal growth factorurogastrone/analysis
