摘要
随着肿瘤分子生物学的进展,人们相继发现胃癌、大肠癌、胰腺癌以及小细胞肺癌等肿瘤均有胃泌素基因的表达,并于其相应的细胞表面发现胃泌素受体。胃癌的发生发展机制至今尚不清楚,导致治疗措施不能尽如人意。胃癌的生长分化受许多因素调控,胃癌细胞的增殖转移与相关胃肠激素密切相关。目前研究提示,与胃癌密切相关的胃肠激素有胃泌素、生长抑素、铃蟾肽、表皮生长因子和胰岛素样生长因子等。现就胃泌素做一综述。
With advancement of tumor molecular biology, the expression of gastrin gene are found in many primary tumors and tumor - derived cell lines, such as gastric cancer, pancreatic cancer and colorectal cance, small - cell lung carcinoma and also has found gastrin receptors on the surface of relevant cells. To date, the pathogenic mechanism of gastric cancer is not clear,Causing measures of therapy unsatisfactory. Growth and differentiation of gastric cancer are regulated by many factors. Related gastroenteric hormones have a close relation to proliferation and metastasis of gastric cancer. At present research suggested, that gastrin, somatostatin, bombesin, epidermal growth factor and insulin - like growth factor, these related gastroenteric hormones have a close relation to gastric cancer. This article reviews about gastrin.
出处
《内蒙古医学院学报》
2008年第1期65-68,72,共5页
Acta Academiae Medicinae Neimongol
基金
呼和浩特市科技局专项基金(2006-农-医-3)
关键词
胃泌素
胃泌素受体
胃肠道肿瘤
gastrin
gastrin receptor
gastrointestinal tumour
作者简介
赵蓓（1979-），女，内蒙古医学院2005级在读硕士研究生。
通讯作者：吴岩，教授，博士，硕士研究生导师，E—mail：yanw007@sina．com内蒙古医学院，010059
