摘要
目的研究穿心莲内酯衍生物的急性毒性。方法采用灌胃和腹腔注射法给药,观察14 d内小鼠的活动情况及死亡情况,用寇氏(krber)法测定穿心莲内酯衍生物对小鼠的半数致死量(LD50)及可信限。结果小鼠给药途径不同毒性表现差别很大,如口服给药的LD50比腹腔注射的LD50大。结论穿心莲内酯衍生物毒性极低,属低毒范围,但对眼睛有一定刺激,对胃有一定影响。
Objective To study the acute toxicity of andrographolide derivatives, Methods Activity condition and death condition of musculus albus were observed within fourteen days with intragastrically and peritoneal injection, and the method of krber was used to determine LD50 of andrographolide derivatives to musculus albus and confidence level. Results and Conclusion The tox- icity manifestation had tremendous difference due to different administration routes, for instance, LD50 of the oral administration was bigger than that of peritoneal injection. The toxicity of andrographolide derivatives is very low, belongs to low toxicity, but those can stimulate eyes and influence stomach to some extent,
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第5期1156-1157,共2页
Lishizhen Medicine and Materia Medica Research
作者简介
翟娜（1980-），女（汉族），河北霸州人，现任河南大学药学院在读硕士研究生，学士学位．主要从事中药药理研究工作
通讯作者：许启泰（1955-），男（汉族），河南周口人，现任河南大学药学院教授，学士学位，主要从事中药药理学研究工作．
