摘要
目的:研究青光眼滤过术后环孢素A缓释系统防止滤过道瘢痕化的作用。方法:新西兰大白兔12只行小梁咬切术,左眼设为实验组,术中植入环孢素A缓释系统(CsA DDS);右眼设为空白对照组,术中植入空白缓释系统,术后观察眼压、滤泡、房闪,定期抽取房水,检测房水中药物浓度。术后7,14,28d分批处死兔子行组织病理学检查。结果:CsA DDS在兔眼表现出良好的局部耐受性;术后3d实验眼滤过泡均值与对照眼无显著性差异,术后7,15,28d实验眼均值高于对照眼,差异有显著性(P<0.05);术后3,7,15,21,28d的5个时间点实验组与对照组眼压差异有显著性(P<0.05);房水中药物浓度随时间推移呈缓慢下降趋势;HE染色观察到约有25%的实验眼切片出现咬切口区堵塞,对照眼所有切片均出现堵塞。结论:CsADDS防止抗青光眼术后滤过道瘢痕化是一种安全、有效的给药方式。
AIM： To study the effect of cyclosporine A （CsA DDS） on the scarring prevention of the filtering passage during glaucoma filtering surgery.
METHODS： Trabeculectomy was performed in 12 New Zealand white rabbits. The left eyes （experimental group） were treated with sustained-release implant of CsA DDS, and the right eye （control group） were treated with the implantation of blank vector during surgery. Intraocular pressure （IOP）, filtering bleb and anterior chamber flare were observed after surgery. Aqueous humor samples were gathered and the concentration of CsA in the aqueous humor was measured. Rabbits were killed on the 7th, 14th and 28th day postoperatively in batch and histopatholoical examination was carried out.
RESULTS： CsA DDS could be well tolerated in rabbit eyes. The average levels of filtering blebs in experimental eyes had no significant difference compared with control eyes at 3 days after surgery, but were significantly higher than those in controls at 7, 15 and 28 days after surgery. The IOP were significantly different between two groups at 3, 7, 15, 21 and 28 days after surgery. The concentration of CsA decreased slowly with time. HE staining showed 25% obstruction of biting site in experimental eyes and 100% obstruction in controls.
CONCLUSION ： CsA DDS is a safe and effective treatment to prevent scarring after glaucoma filtering surgery.
出处
《国际眼科杂志》
CAS
2008年第5期890-892,共3页
International Eye Science
基金
中国陕西省科技计划项目(No2003k10-G113)~~
关键词
青光眼滤过术
环孢素A缓释系统
抗增殖
glaucoma filtering surgery
cyclosporine A sustained release system
anti-proliferation
作者简介
裴澄，男，博士，主治医师。通讯作者：裴澄．peich71@163．com
