摘要
目的总结多发性硬化（MS）患者的临床特点和治疗转归。方法用临床病例分析统计方法，对30例MS患者的发病规律、临床特点进行归纳分析。结果30例MS病例中，临床确诊25例，实验室支持确诊3例，临床可能2例；男性9例。女性21例；发病年龄15～64岁，平均39．22±13．44岁；80％的病例以急性或亚急性起病；58．33％的病例病前有诱发因素，其中33，33％与感染有关；首发症状以视力障碍、肢体无力和感觉障碍最为常见；10％的病例合并周围神经损害；血清尿酸降低更多见于扩充致残量表评分（EDSS评分）〉4．5分病例。脑脊液异常主要表现为蛋白升高、寡克隆带阳性、24h鞘内合成率升高和髓鞘碱性蛋白（MBP）升高；63，16％的病例出现头颅磁共振成像（MRI）I异常信号；脊髓MRI异常率为100％。结论本组MS病例病前多有诱发因素；以视神经和脊髓病变最为常见；合并有周围神经系统损害；脑脊液检查和MRI等影像学检查对疾病诊断有帮助。
Objective To summarize the features of multiple sclerosis. Methods The clinical manifestations and inducements of 30 MS patients are comprehensively analyzed by using clinical statistical method. Results Among 30 MS cases, there are 25 clinically confirmed MS patients, 3 laboratory supported definite MS patients and 2 clinically or laboratory favouring MS patients. Among them, 9 are males and 21 females, The age ranges for first onset are from 15 to 64 years old. 80% of them have acute or subacute clinical courses. The abnormal changes in CSF are mainly manifested as increased protein content, raised 24 h synthetic rate of IgG and myelin basic protein （MBP） and positive oligoclonal bands in most cases. Abnormalities in cerebral and spinal cord MRI were found in 63.16% and 100% cases respectively. Conclusion Optic nerve and spinal cord are easily to be involved, and MRI is helpful in diagnosis of MS.
出处
《临床和实验医学杂志》
2008年第7期19-20,共2页
Journal of Clinical and Experimental Medicine
