期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

两种生物素杂质的合成 被引量：2

Synthesis of two impurities of d-biotin
在线阅读 下载PDF
导出
摘要 Two impurities of d-biotin are synthesized:di[3-[(3aS,4S,6aR)-2-oxohexahydrothienoimidazol-4-yl]propyl]acetic acid,4-[(3aS,4S,6aR)-2-oxohexahydrothienoimidazol-4-yl]butane-1,1-dicarboxylic acid.Structure of target compounds are confirmed by 1HNMR.This work further improve the research on the impurities of d-biotin,and can be applied to the quality control and quality assurance of d-biotin. Two impurities of d-biotin are synthesized： di[3-[（3aS, 4S, 6aR）-2-oxohexahydrothieno [ 3,4-d ] imidazol-4-yl ] propyl ] acetic acid, 4-[（3aS, 4S, 6aR）- 2-oxohexahydrothieno [ 3,4-d ] imidazol-4-yl ] butane-1,1-dicarboxylic acid. Structure of target compounds are confirmed by ^1HNMR. This work further improve the research on the impurities of d-biotin, and can be applied to the quality eontrol and quality assurance of d-biotin.
作者 陈建辉 吴志刚 赵洪山 叶伟东 王月英
机构地区 浙江医药股份有限公司新昌制药厂
出处 《化学研究与应用》 CAS CSCD 北大核心 2008年第7期913-915,共3页 Chemical Research and Application
基金 国家科技兴贸行动专项(2006GH553302) 浙江省重大科技专项(2006C11190) 国家技术发明二等奖(2005-F-213-2-02-R02)
关键词 生物素 杂质 合成 d-biotin impurities synthesis
分类号 R914.5 [医药卫生—药物化学]
作者简介 联系人简介：陈建辉（1971-），男，高级工程师，从事新药合成。Email：chenjianhui-2005@shou．com
  • 相关文献

参考文献11

  • 1Mistry P S, Dakshinamurti K. Biochemistry of biotin [ J ], Vitam. Horm. , 1964,22 : 1-55.
  • 2Coggeshall, C J, Heggers P J, Robson, C M, et al. Biotin status and plasma glucose in diabetics [ J ]. Ann. NY Acad. Sci. , 1985,447:389-392.
  • 3Maebashi M, Makino Y, Furukawa Y, et al. Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin dependent diabetes mellitus [ J ]. J. Clin. Biochem. Nutr. , 1993,14:211-218.
  • 4McCormick D B. Biotin [ J ] . Nutr. Rev. , 1975,33 : 97 - 102.
  • 5欧洲药典委员会,欧洲药典[S],EP5.0,2005:1073,1100.1101.
  • 6美国药典委员会,美国药典[S],USP28,2005:230.
  • 7Cheney L C, Piening J R. The total synthesis of 2,3,4,5- tetradedrobiotin [ J ]. J Am. Chem. Soc. , 1945, 67:731-735.
  • 8Nishimura S,Imoto E. Studies on thiophene compounds. XIX. syntheses of 2,3,4,5-tetradehydrobiotin and 2,3,4, 5-tetradehydronorbiotin [ J ]. Bull. Chem. Soc. Jpn. , 1962, 35:432-437.
  • 9Hanka L J, D G Martin, L M Reineke. Two new antimetabolites of biotin: α-methyldethiobiotin and α- methylbiotin [ J ]. Antimicrob. Agents Chemother. , 1972,1 : 135-138.
  • 10Dixon R W, Radmer R J, Kuhn B, et al. Theoretical and experimental studies of biotin analogues that bind almost as tightly to streptavidin as biotin [ J ] J. Org. Chem,2002,67 : 1827-1837.

共引文献1

同被引文献20

  • 1潘林,孙建义.生物素的生理功能及其分子作用机制[J].中国饲料,2005(6):21-24. 被引量：20
  • 2Dixon R. W. , Radmer R. J. , Kuhn B. , and KoUman P. A. Theoretical and experimental studies of biotin analogues that bind almost as tightly to streptavidin as biotin[ J ]. J. Org. Chem. 2002,67,1827-1837
  • 3Corey E J, Mehrotra M M. A simple and enantioseleetive synthesis of( + ) -biotin [ J ]. Tetrahedron Lett. 1988,29 (1):57 -60.
  • 4陈芬儿.d-生物素的合成方法[P].中国专利:CN02111173.1,2002-03-27
  • 5Mistry, P. S. ; Dakshinamurti, K. Biochemistry of biotin [ J ]. Vitam. Horm. , 1964,22,1-55.
  • 6CoggeshaU, C. J. ; Heggers,P. J. ; Robson,C. M. ; Baker, H. Biotin status and plasma glucose in diabetics [ J ]. Ann. NY Acad. Sci. , 1985,447,389-392.
  • 7Maebashi M, Makino Y, Furukawa Y, Ohinata K, Kimura S, Sato T. Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin dependent diabetes mellitus [ J ]. J. Clin. Biochem. Nutr. , 1993 ; 14 : 211-215.
  • 8McCormick, D. B. Biotin [ J ]. Nutr. Rev. ( 1975 ) 33 : 97-102
  • 9欧洲药典委员会.欧洲药典[S].EP5.0,2005:1073,1100.1101.
  • 10Cheney, L. C. ; Piening,J. R. The total synthesis of 2,3,4,5-tetradedrobiotin [ J ] J. Am. Chem. Soc. , 1945, 67, 731-735.

引证文献2

二级引证文献2

化学研究与应用
2008年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
关于我们 | 版权声明 | 联系我们 | 帮助中心| 意见反馈
主办单位：上海市教育委员会
技术支持：重庆维普资讯有限公司
渝公网安备 50019002500403号
使用帮助 返回顶部