摘要
With the illustration of the L-Arg-NO-cGMP pathway in penile erection,the researches on nitric oxide synthases(NOSs),which produce nitric oxide(NO)as the main messenger to control the process,has stayed in the spotlight.nNOS locates in neuroal tissues and eNOS is binding on the membrane of cavernous sinus endothelium with caveolin.The nNOS & eNOS are expressed constitutively.The activation of nNOS & eNOS is more dependent on Ca2+ concentration than iNOS,which is seldom expressed except in aged or pathological conditions.It is now clear that nNOS may initiate cavernosal tissue relaxation under the regulation of PDZ zone when transcripted,while phosphorylated eNOS may facilitate attainment and maintenance of full erection.iNOS expression stimulated by the cytokines may be beneficial(cytoprotective or anti-fibrotic)or deleterious(cytotoxic)according to the tissue environment.Gene therapies based on NOSs have attained a great deal of achievements in animal experiments and will promise a wonderful future.
With the illustration of the L - Arg - NO - cGMP pathway in penile erection, the researches on nitric oxide synthases （ NOSs ）, which produce nitric oxide （NO） as the main messenger to control the process, has stayed in the spotlight, nNOS locates in neuroal tissues and eNOS is binding on the membrane of cavernous sinus endothelium with caveolin. The nNOS ＆ eNOS are expressed constitutively. The activation of nNOS ＆ eNOS is more dependent on Ca^2＋ concentration than iNOS, which is seldom expressed except in aged or pathological conditions. It is now clear that nNOS may initi- ate cavernosal tissue relaxation under the regulation of PDZ zone when transcripted, while phosphorylated eNOS may facili- tate attainment and maintenance of full erection, iNOS expression stimulated by the cytokines may be beneficial （ cytopro- tective or anti-fibrotic） or deleterious （cytotoxic） according to the tissue environment. Gene therapies based on NOSs have attained a great deal of achievements in animal experiments and will promise a wonderful future.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2008年第7期1449-1453,共5页
Chinese Journal of Pathophysiology
基金
上海市科委科研计划资助项目(No.044119718)
关键词
勃起功能障碍
一氧化氮合酶
Erectile dysfunction
Nitric- oxide synthase
作者简介
通讯作者Tel：021—53882063；E-mail：binchen@263．sina．com
