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单核苷酸多态性及其在水产动物遗传育种中的应用 被引量:25

Single nucleotide polymorphisms and its application in genetic breeding of aquatic animals
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摘要 单核苷酸多态性(SNPs)是广泛存在于基因组中的一类由单个碱基转换或颠换引起的DNA序列多态性。它是继限制性片段长度多态性(RFLP)、微卫星标记(SSR)之后的新一代分子标记,已广泛应用于构建遗传连锁图谱、QTL定位、关联分析及研究群体遗传结构与亲缘关系等方面。本文主要介绍了SNPs的概念、特点及检测SNPs的主要方法,综述了SNPs在水产动物遗传育种中的研究进展,以期将SNPs更广泛地应用于水产动物群体遗传、分子标记辅助育种和生物进化等研究领域。 Single nucleotide polymorphisms (SNPs) consist of a single nucleotide base alteration which included transition and transversion. As a new moclecular marker following restriction fragment length polymorphism (RFLP) and simple sequence repeat (SSR), SNPs are used widely in genetic linkage maps, quantitative trait loci location, association studies, population genetics structure and genetics relationship. The conception, characteristics, detection methods, and advancement in genetic breeding of aquatic animals were introduced in this review. It is anticipated that SNPs marker will contribute greatly to studies on aquatic animals population genetics, molecular breeding as well as evolutionary biology.
出处 《中国水产科学》 CAS CSCD 北大核心 2008年第4期704-712,共9页 Journal of Fishery Sciences of China
基金 农业部948项目(2006-G55) 国家科技支撑计划(2006BAD01A1209) 国家科技基础条件平台工作项目(2005DKA21103)
关键词 单核苷酸多态性 分子标记 水产动物 遗传育种 single nucleotide polymorphisms molecular markers aquatic animals genetic breeding
作者简介 刘福平(1983-),男,在读硕士研究生,从事水产动物遗传育种研究. 通讯作者:白俊杰.Tel:020-81616129;E-mail:jjbai@163.net
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