摘要
目的:探讨氯沙坦对血管紧张素Ⅱ(AngⅡ)诱导巨噬细胞MMP-9表达的影响。方法:体外培养巨噬细胞,测定AngⅡ诱导巨噬细胞MMP-9表达及氯沙坦的干预作用。结果:AngⅡ组MMP-9表达明显高于对照组(P<0.05),且1×10-7mol/LAngⅡ亚组MMP-9表达明显高于对照组(P<0.01);AngⅡ+氯沙坦组MMP-9表达明显低于AngⅡ组(P<0.05)。结论:氯沙坦可阻断AngⅡ与AT1受体结合,下调巨噬细胞MMP-9的表达。
Objective：To study the impact of losartan on matrix metalloproteinase-9 （MMP-9） expression in macrophage of angiotensin Ⅱ -induced. Methods：To observe MMP-9 expression of angiotensin Ⅱ-induced in macrophage to culture in vitro and the role of losartan. Results：MMP-9 expression in angiotensin Ⅱ group was significantly higher than that in control group （P〈0.05）, and MMP-9 expression in 1×10^-7 mol/L angiotensin Ⅱ subset was significantly higher than that in control group （P〈0.01）; angiotensin Ⅱ ＋ losartan group was significantly lower than that in angiotensin Ⅱ group （P〈0.05）. Conclusion：Losartan maybe obstruct the combination of Ang Ⅱ and AT1 receptor to down-regulate the MMP-9 expression in macrophage.
出处
《中国医药导报》
CAS
2008年第18期182-183,共2页
China Medical Herald
